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Query: NC_015848:1105892:1118250 Mycobacterium canettii CIPT 140010059, complete genome

Start: 1118250, End: 1118906, Length: 657

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:1095846:110821111082111108867657Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein2e-82304
NC_002945:1095337:110789411078941108550657Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-82304
NC_008769:1125567:113793211379321138588657Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-82304
NC_012207:1097228:110959311095931110249657Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-82304
NC_002755:1095105:110748211074821108138657Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein4e-82303
NC_000962:1095078:110744311074431108099657Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein4e-82303
NC_009525:1096386:110875111087511109407657Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein4e-82303
NC_017026:1095753:110813011081301108786657Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein3e-81301
NC_016768:3296478:330060233006023301258657Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein3e-81301
NC_012943:3299744:330386833038683304524657Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein3e-81301
NC_009565:1098847:111121111112111111867657Mycobacterium tuberculosis F11, complete genomehypothetical protein3e-81301
NC_013510:991827:1006923100692310080591137Thermomonospora curvata DSM 43183, complete genomeSAF domain protein5e-0651.2