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Query: NC_015848:1105892:1115923 Mycobacterium canettii CIPT 140010059, complete genome

Start: 1115923, End: 1117083, Length: 1161

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016768:3296478:3302425330242533035851161Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein0705
NC_012943:3299744:3305691330569133068511161Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein0705
NC_009525:1096386:1106424110642411075841161Mycobacterium tuberculosis H37Ra, complete genomeputative conserved exported protein0705
NC_009565:1098847:1108884110888411100441161Mycobacterium tuberculosis F11, complete genomehypothetical protein0705
NC_000962:1095078:1105116110511611062761161Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE CONSERVED EXPORTED PROTEIN0705
NC_002755:1095105:1105155110515511063151161Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein0705
NC_002945:1095337:1105567110556711067271161Mycobacterium bovis AF2122/97, complete genomehypothetical protein0702
NC_008769:1125567:1135605113560511367651161Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein0702
NC_012207:1097228:1107266110726611084261161Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein0702
NC_016804:1095846:1105884110588411070441161Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein0702
NC_002939:2337402:2395548239554823967171170Geobacter sulfurreducens PCA, complete genomehypothetical protein5e-70265
NC_017026:1095753:110623111062311106734504Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein8e-70264
NC_007492:2310793:2313904231390423149711068Pseudomonas fluorescens PfO-1, complete genomehypothetical protein1e-43177
NC_009348:2738742:2742461274246127435281068Aeromonas salmonicida subsp. salmonicida A449, complete genomehypothetical protein2e-41169
NC_009952:3522370:3522370352237035234341065Dinoroseobacter shibae DFL 12, complete genomehypothetical protein2e-40167
NC_015733:3595882:3599086359908636001411056Pseudomonas putida S16 chromosome, complete genomeputative lipoprotein4e-39162
NC_011662:2402408:2418887241888724200501164Thauera sp. MZ1T, complete genomehypothetical protein5e-38159
NC_013939:1902397:1903082190308219041161035Deferribacter desulfuricans SSM1, complete genomehypothetical protein3e-35149
NC_008700:3514745:3520925352092535221271203Shewanella amazonensis SB2B, complete genomeconserved hypothetical protein3e-33142
NC_012721:2556160:2596395259639525974561062Burkholderia glumae BGR1 chromosome 2, complete genomeSecreted hydrolase-like protein3e-29129
NC_012721:2556160:2597551259755125986241074Burkholderia glumae BGR1 chromosome 2, complete genomehypothetical protein5e-1685.9
NC_019673:3559185:3564511356451135655811071Saccharothrix espanaensis DSM 44229 complete genomeputative hydrolase5e-1168.9
NC_011837:2856500:2869270286927028703221053Clostridium kluyveri NBRC 12016, complete genomehypothetical protein7e-0962
NC_009706:2925000:2937768293776829387691002Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein7e-0962
NC_015727:764744:764744764744765091348Cupriavidus necator N-1 plasmid BB1p, complete sequencesecreted hydrolase2e-0653.9