Pre_GI: BLASTP Hits

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Query: NC_015571:290355:311252 Porphyromonas gingivalis TDC60, complete genome

Start: 311252, End: 313795, Length: 2544

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002950:2098454:2114946211494621174892544Porphyromonas gingivalis W83, complete genomehypothetical protein01448
NC_015164:2683162:2704448270444827069402493Bacteroides salanitronis DSM 18170 chromosome, complete genomehypothetical protein8e-176617
NC_009615:3308538:3312194331219433146982505Parabacteroides distasonis ATCC 8503 chromosome, complete genomehypothetical protein4e-101369
NC_016940:2843500:2856251285625128590012751Saprospira grandis str. Lewin chromosome, complete genomehypothetical protein4e-75283
NC_011060:244949:2537062537062561622457Pelodictyon phaeoclathratiforme BU-1, complete genomehypothetical protein3e-1894.4