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Query: NC_015571:168617:188619 Porphyromonas gingivalis TDC60, complete genome

Start: 188619, End: 189296, Length: 678

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002950:1981155:199614319961431996820678Porphyromonas gingivalis W83, complete genomethiamin pyrophosphokinase catalytic domain protein4e-130463
NC_009615:4304158:431867243186724319331660Parabacteroides distasonis ATCC 8503 chromosome, complete genomehypothetical protein6e-38157
NC_006347:700838:723011723011723634624Bacteroides fragilis YCH46, complete genomehypothetical protein4e-29127
NC_003228:648669:670836670836671459624Bacteroides fragilis NCTC 9343, complete genomehypothetical protein5e-29127
NC_017365:77150:977299772998343615Helicobacter pylori F30, complete genomehypothetical protein2e-26119
NC_017355:1299874:129987412998741300488615Helicobacter pylori v225d chromosome, complete genomethiamine pyrophosphokinase9e-26117
NC_000921:1343701:134370113437011344315615Helicobacter pylori J99, complete genomehypothetical protein9e-26117
NC_011498:1345623:134562313456231346237615Helicobacter pylori P12, complete genomehypothetical protein7e-26117
NC_014560:1309470:130947013094701310084615Helicobacter pylori SJM180 chromosome, complete genomethiamine pyrophosphokinase5e-26117
NC_017372:1373766:137376613737661374380615Helicobacter pylori India7 chromosome, complete genomethiamine pyrophosphokinase1e-25116
NC_017375:1317398:131739813173981318012615Helicobacter pylori 83 chromosome, complete genomethiamine diphosphokinase2e-25115
NC_017367:1333811:133381113338111334425615Helicobacter pylori F57, complete genomehypothetical protein9e-25113
NC_016584:4905310:491598149159814916631651Desulfosporosinus orientis DSM 765 chromosome, complete genomethiamine pyrophosphokinase3e-1272.4
NC_018515:3909646:392140439214043922060657Desulfosporosinus meridiei DSM 13257 chromosome, complete genomethiamine pyrophosphokinase9e-0960.5
NC_018664:1729794:175009217500921750724633Clostridium acidurici 9a chromosome, complete genomethiamine pyrophosphokinase ThiN1e-0860.5
NC_009012:686740:705303705303705941639Clostridium thermocellum ATCC 27405, complete genomethiamine pyrophosphokinase1e-0653.5