Pre_GI: BLASTP Hits

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Query: NC_015571:168617:179039 Porphyromonas gingivalis TDC60, complete genome

Start: 179039, End: 179452, Length: 414

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015571:168617:1721271721271784506324Porphyromonas gingivalis TDC60, complete genomehypothetical protein8e-0752.4
NC_016610:1974527:1979961197996119814121452Tannerella forsythia ATCC 43037 chromosome, complete genomeRHS repeat-associated core domain-containing protein1e-0652