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Query: NC_015425:369225:376392 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 376392, End: 377366, Length: 975

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016012:16134:209632096321931969Candidatus Arthromitus sp. SFB-rat-Yit, complete genome3'-5' exoribonuclease YhaM1e-80300
NC_014624:171394:177900177900178844945Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein8e-68257
NC_014915:595569:620255620255621232978Geobacillus sp. Y412MC52 chromosome, complete genomemetal dependent phosphohydrolase1e-57223
NC_013411:1454465:1480311148031114814411131Geobacillus sp. Y412MC61, complete genomemetal dependent phosphohydrolase1e-57223
NC_016935:4038265:403826540382654039221957Paenibacillus mucilaginosus 3016 chromosome, complete genomemetal dependent phosphohydrolase7e-57221
NC_015690:3477573:347956534795653480521957Paenibacillus mucilaginosus KNP414 chromosome, complete genomemetal dependent phosphohydrolase1e-56220
NC_014727:1512546:151160315116031512553951Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,3'-5' exoribonuclease yham1e-41170
NC_020409:512861:5202845202845213121029Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completeMetal dependent phosphohydrolase5e-39161
NC_015977:255029:258977258977259930954Roseburia hominis A2-183 chromosome, complete genomeHD-superfamily hydrolase8e-32137
NC_014836:1108919:1110033111003311111601128Desulfurispirillum indicum S5 chromosome, complete genomemetal dependent phosphohydrolase7e-29128
NC_015573:2323268:234095223409522341893942Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomemetal dependent phosphohydrolase1e-25117
NC_021184:1484352:150165815016581502599942Desulfotomaculum gibsoniae DSM 7213, complete genomeputative HD superfamily hydrolase7e-25114
NC_009943:1364536:139000513900051390967963Candidatus Desulfococcus oleovorans Hxd3, complete genomemetal dependent phosphohydrolase4e-23108
NC_009922:2487492:249407024940702495044975Alkaliphilus oremlandii OhILAs, complete genomemetal dependent phosphohydrolase3e-22105
NC_014220:70490:7198871988730041017Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomemetal dependent phosphohydrolase1e-1170.9
NC_010516:3466000:348381934838193484715897Clostridium botulinum B1 str. Okra, complete genomeHDIG domain protein4e-0962.4
NC_009698:3275839:328860332886033289499897Clostridium botulinum A str. Hall chromosome, complete genomeHDIG domain-containing protein4e-0962.4