Pre_GI: BLASTP Hits

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Query: NC_015425:198315:221558 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 221558, End: 222268, Length: 711

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:196257:216937216937217596660Clostridium novyi NT, complete genomeRNA polymerase sigma-H factor7e-101366
NC_021182:4557608:459439445943944595038645Clostridium pasteurianum BC1, complete genomeRNA polymerase sigma-H factor2e-89328
NC_009698:3553365:359847835984783599119642Clostridium botulinum A str. Hall chromosome, complete genomeRNA polymerase factor sigma-703e-86318
NC_012563:3956500:399330639933063993947642Clostridium botulinum A2 str. Kyoto, complete genomeRNA polymerase sigma-H factor3e-86318
NC_010520:3788702:382597838259783826619642Clostridium botulinum A3 str. Loch Maree, complete genomeRNA polymerase sigma-H factor3e-86318
NC_010516:3759136:379637737963773797018642Clostridium botulinum B1 str. Okra, complete genomeRNA polymerase sigma-H factor3e-86318
NC_009495:3688138:372538037253803725952573Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeRNA polymerase factor sigma-702e-84311
NC_014393:4482896:452051745205174521170654Clostridium cellulovorans 743B chromosome, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily3e-84311
NC_010674:222016:231001231001231621621Clostridium botulinum B str. Eklund 17B, complete genomeRNA polymerase sigma-H factor6e-84310
NC_010723:223935:232933232933233553621Clostridium botulinum E3 str. Alaska E43, complete genomeRNA polymerase sigma-H factor4e-84310
NC_017295:3250451:328740932874093288047639Clostridium acetobutylicum EA 2018 chromosome, complete genomeRNA polymerase factor sigma-701e-81302
NC_015687:3252233:328977932897793290417639Clostridium acetobutylicum DSM 1731 chromosome, complete genomeRNA polymerase factor sigma-701e-81302
NC_003030:3251941:328815232881523288790639Clostridium acetobutylicum ATCC 824, complete genomeRNA polymerase sigma-70 factor3e-81301
NC_008262:2598920:263694326369432637590648Clostridium perfringens SM101, complete genomeRNA polymerase sigma-H factor1e-79296
NC_020291:166500:175261175261175881621Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeRNA polymerase sigma-H factor SigH1e-78293
NC_009633:4563877:459642045964204597061642Alkaliphilus metalliredigens QYMF chromosome, complete genomeRNA polymerase factor sigma-706e-78290
NC_009617:163466:173671173671174342672Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeRNA polymerase factor sigma-709e-78289
NC_010424:214640:219240219240219890651Candidatus Desulforudis audaxviator MP104C, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily4e-77287
NC_013216:293571:293571293571294215645Desulfotomaculum acetoxidans DSM 771, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily4e-76284
NC_015958:2251619:231219523121952312839645Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeECF subfamily RNA polymerase sigma-24 subunit SigH3e-74277
NC_010321:393000:400932400932401576645Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeRNA polymerase factor sigma-706e-74276
NC_010320:881351:886863886863887507645Thermoanaerobacter sp. X514 chromosome, complete genomeRNA polymerase factor sigma-706e-74276
NC_014964:388458:396348396348396992645Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeRNA polymerase sigma-H factor6e-74276
NC_014220:2265882:227790422779042278557654Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily1e-73276
NC_010718:193231:199476199476200117642Natranaerobius thermophilus JW/NM-WN-LF, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily4e-73274
NC_014410:403776:411426411426412070645Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,RNA polymerase, sigma-24 subunit, ECF subfamily9e-72270
NC_014171:109280:109860109860110519660Bacillus thuringiensis BMB171 chromosome, complete genomeRNA polymerase factor sigma-709e-72270
NC_017208:108134:111911111911112570660Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeRNA polymerase factor sigma-708e-72270
NC_019970:336472:364927364927365571645Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeRNA polymerase sigma-H factor1e-71269
NC_015555:327562:335253335253335897645Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeRNA polymerase, sigma-24 subunit, SigH, ECF subfamily2e-71268
NC_017294:1457262:148663114866311487272642Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomeRNA polymerase sigma-H factor4e-68257
NC_015913:1491393:152024115202411520882642Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomeRNA polymerase factor sigma-704e-68257
NC_010382:4479464:448226744822674482914648Lysinibacillus sphaericus C3-41, complete genomeRNA polymerase sigma-H factor (sigma-30)3e-67254
NC_013316:81969:867408674087402663Clostridium difficile R20291, complete genomeRNA polymerase sigma-H factor7e-67253
NC_004193:119737:122942122942123595654Oceanobacillus iheyensis HTE831, complete genomeRNA polymerase sigma-70 factor2e-64245
NC_019978:178277:179975179975180622648Halobacteroides halobius DSM 5150, complete genomeRNA polymerase sigma-H factor6e-61233
NC_015520:2280643:230498623049862305636651Mahella australiensis 50-1 BON chromosome, complete genomeRNA polymerase sigma-30 subunit SigH1e-58226
NC_014652:757381:775730775730776464735Caldicellulosiruptor hydrothermalis 108 chromosome, completeRNA polymerase, sigma-24 subunit, ecf subfamily2e-57222
NC_014392:1935130:195037219503721951106735Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily2e-57221
NC_019978:2260395:228220222822022282888687Halobacteroides halobius DSM 5150, complete genomeRNA polymerase sigma factor, sigma-70 family2e-41169
NC_015737:2146953:214637521463752146956582Clostridium sp. SY8519, complete genomeDNA-directed RNA polymerase specialized sigma subunit4e-31134
NC_013205:576583:602372602372603001630Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,RNA polymerase, sigma-24 subunit, ECF subfamily3e-22105
NC_013207:19154:401344013440763630Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446RNA polymerase, sigma-24 subunit, ECF subfamily9e-22103
NC_017167:1648913:171892317189231719552630Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1ECF subfamily RNA polymerase sigma-24 subunit8e-21100
NC_017167:2298962:232631423263142326943630Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1ECF subfamily RNA polymerase sigma-24 subunit9e-21100
NC_012673:2023297:202719120271912027991801Exiguobacterium sp. AT1b, complete genomeRNA polymerase, sigma 28 subunit, Sig B/F/G subfamily1e-0757
NC_014219:567033:568900568900569706807Bacillus selenitireducens MLS10 chromosome, complete genometranscriptional regulator, LuxR family2e-0755.8
NC_017191:467207:467981467981468769789Bacillus amyloliquefaciens XH7 chromosome, complete genomeRNA polymerase sigma factor SigB3e-0755.5
NC_017190:466236:466684466684467472789Bacillus amyloliquefaciens LL3 chromosome, complete genomeRNA polymerase sigma-37 factor (sigma(B))3e-0755.5
NC_017188:461177:461951461951462739789Bacillus amyloliquefaciens TA208 chromosome, complete genomeRNA polymerase sigma factor SigB3e-0755.5
NC_014551:483773:484547484547485335789Bacillus amyloliquefaciens DSM 7, complete genomeRNA polymerase sigma-37 factor (sigma(B))3e-0755.5
NC_020410:495184:495958495958496746789Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completeRNA polymerase sigma-B factor3e-0755.5
NC_009725:496443:497217497217498005789Bacillus amyloliquefaciens FZB42, complete genomeSigB3e-0755.5
NC_019842:484933:485381485381486169789Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,RNA polymerase sigma factor SigB3e-0755.5
NC_009922:2721343:273475927347592735331573Alkaliphilus oremlandii OhILAs, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily4e-0755.1
NC_019978:2036779:205421120542112054906696Halobacteroides halobius DSM 5150, complete genomeRNA polymerase sigma-K factor4e-0755.1
NC_004193:375416:655820655820656611792Oceanobacillus iheyensis HTE831, complete genomesigma factor B1e-0653.5
NC_004193:375416:375416375416675301299886Oceanobacillus iheyensis HTE831, complete genome1e-0653.1
NC_008710:819389:820347820347821150804Borrelia turicatae 91E135, complete genomeRNA polymerase sigma factor RpoS2e-0653.1
NC_000964:521975:522417522417523211795Bacillus subtilis subsp. subtilis str. 168, complete genomesigma factor B2e-0653.1
NC_019748:4129500:4144777414477741460271251Stanieria cyanosphaera PCC 7437, complete genomeRNA polymerase, sigma subunit, RpsC/SigC2e-0653.1
NC_014976:2735423:273726627372662738054789Bacillus subtilis BSn5 chromosome, complete genomeRNA polymerase sigma factor SigB2e-0653.1
NC_016047:637778:639621639621640409789Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completeRNA polymerase sigma-B factor2e-0653.1
NC_008346:584305:613841613841614575735Syntrophomonas wolfei subsp. wolfei str. Goettingen, completesigma 28 (flagella/sporulation)2e-0652.8
NC_014479:509919:510693510693511481789Bacillus subtilis subsp. spizizenii str. W23 chromosome, completeRNA polymerase sigma factor SigB2e-0652.8
NC_007413:1405817:1426867142686714281171251Anabaena variabilis ATCC 29413, complete genomeRNA polymerase sigma-like factor3e-0652
NC_014657:914071:916231916231917052822Caldicellulosiruptor owensensis OL chromosome, complete genomeRNA polymerase, sigma 70 subunit, rpod subfamily3e-0652
NC_019896:3491000:351722135172213518015795Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completeRNA polymerase sigma factor SigB4e-0652
NC_014330:697429:713067713067713921855Brachyspira pilosicoli 95/1000 chromosome, complete genomeDNA directed RNA polymerase sigma subunit5e-0651.2
NC_019908:2496149:250468525046852505539855Brachyspira pilosicoli P43/6/78 chromosome, complete genomeDNA directed RNA polymerase sigma subunit5e-0651.2
NC_006582:883922:886206886206886991786Bacillus clausii KSM-K16, complete genomesigma factor B7e-0650.8
NC_011661:1332309:1332309133230913335501242Dictyoglomus turgidum DSM 6724, complete genomeputative RNA polymerase, sigma 70 family subunit7e-0650.8