Pre_GI: BLASTP Hits

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Query: NC_015425:198315:219428 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 219428, End: 220162, Length: 735

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:196257:214749214749215483735Clostridium novyi NT, complete genomethymidylate synthase, flavin-dependent2e-126451
NC_008262:2598920:263908926390892639826738Clostridium perfringens SM101, complete genomethymidylate synthase, flavin-dependent5e-106383
NC_012563:3956500:399530939953093996061753Clostridium botulinum A2 str. Kyoto, complete genomethymidylate synthase, flavin-dependent2e-102372
NC_010516:3759136:379838037983803799132753Clostridium botulinum B1 str. Okra, complete genomethymidylate synthase, flavin-dependent3e-102371
NC_010520:3788702:382798138279813828733753Clostridium botulinum A3 str. Loch Maree, complete genomethymidylate synthase, flavin-dependent4e-102370
NC_021182:4557608:459649345964934597302810Clostridium pasteurianum BC1, complete genomethymidylate synthase, flavin-dependent8e-102369
NC_014614:2333890:233389023338902334660771Clostridium sticklandii, complete genomeThymidylate synthase thyX (TS) (TSase)1e-90332
NC_014392:1935130:195234119523411953132792Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomethymidylate synthase, flavin-dependent6e-84310
NC_014652:757381:773704773704774495792Caldicellulosiruptor hydrothermalis 108 chromosome, completethymidylate synthase, flavin-dependent5e-84310
NC_009633:4563877:459844945984494599222774Alkaliphilus metalliredigens QYMF chromosome, complete genomeFAD-dependent thymidylate synthase1e-83309
NC_014220:2265882:228001622800162280816801Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomethymidylate synthase, flavin-dependent1e-82306
NC_015672:2071141:208616420861642086898735Flexistipes sinusarabici DSM 4947 chromosome, complete genomeThymidylate synthase thyX3e-66251
NC_013939:106681:109399109399110130732Deferribacter desulfuricans SSM1, complete genomeFAD-dependent thymidylate synthase4e-66251
NC_010424:214640:217073217073217810738Candidatus Desulforudis audaxviator MP104C, complete genomethymidylate synthase, flavin-dependent1e-58226
NC_012883:1421644:142410114241011424877777Thermococcus sibiricus MM 739, complete genomeThymidylate synthase thyX8e-44177
NC_009253:1265474:127744912774491278120672Desulfotomaculum reducens MI-1 chromosome, complete genomethymidylate synthase, flavin-dependent1e-37156
NC_014374:1072218:1122221112222111232221002Acidilobus saccharovorans 345-15 chromosome, complete genomepredicted alternative thymidylate synthase1e-35149
NC_014160:869873:871918871918872865948Thermosphaera aggregans DSM 11486 chromosome, complete genomethymidylate synthase4e-33141
NC_014961:1071424:109263510926351093567933Desulfurococcus mucosus DSM 2162 chromosome, complete genomethymidylate synthase (FAD)1e-32139
NC_011766:1035858:105515010551501056049900Desulfurococcus kamchatkensis 1221n chromosome, complete genomethymidylate synthase, flavin-dependent2e-32139
NC_002936:1319266:134694413469441347531588Dehalococcoides ethenogenes 195, complete genomethymidylate synthase, flavin-dependent1e-30133
NC_017954:345430:346392346392347309918Thermogladius cellulolyticus 1633 chromosome, complete genomethymidylate synthase, flavin-dependent3e-29129
NC_014205:1331594:135036613503661351340975Staphylothermus hellenicus DSM 12710 chromosome, complete genomethymidylate synthase, flavin-dependent5e-28124
NC_002677:1822500:182564518256451826409765Mycobacterium leprae TN, complete genomethymidylate synthase2e-27122
NC_016816:674171:683133683133683951819Pantoea ananatis LMG 5342, complete genomeFAD-dependent thymidylate synthase2e-24112
NC_015572:1:512725127252078807Methylomonas methanica MC09 chromosome, complete genomeThymidylate synthase thyX3e-21102
NC_013316:81969:851088510885410303Clostridium difficile R20291, complete genomeputative thymidylate synthase2e-1996.3
NC_014537:1454618:145384314538431454631789Vulcanisaeta distributa DSM 14429 chromosome, complete genomethymidylate synthase, flavin-dependent2e-1892.8
NC_016801:1123733:112936711293671130083717Corynebacterium diphtheriae C7 (beta) chromosome, complete genomeFAD-dependent thymidylate synthase9e-1787
NC_010718:193231:197201197201197893693Natranaerobius thermophilus JW/NM-WN-LF, complete genomethymidylate synthase, flavin-dependent6e-1684.7
NC_014802:27857:317693176932392624Campylobacter jejuni subsp. jejuni ICDCCJ07001 chromosome, completethymidylate synthase2e-1582.4
NC_008787:31999:335043350434127624Campylobacter jejuni subsp. jejuni 81-176, complete genomethymidylate synthase, flavin-dependent2e-1582.4
NC_003912:30265:317703177032393624Campylobacter jejuni RM1221, complete genomethymidylate synthase2e-1582.4
NC_002163:29726:336393363934262624Campylobacter jejuni subsp. jejuni NCTC 11168, complete genomethymidylate synthase2e-1582.4
NC_017279:29737:336503365034273624Campylobacter jejuni subsp. jejuni IA3902 chromosome, completeFAD-dependent thymidylate synthase2e-1582.4
NC_017280:30388:318933189332516624Campylobacter jejuni subsp. jejuni M1 chromosome, complete genomethymidylate synthase ThyX2e-1582.4
NC_017281:30261:317663176632389624Campylobacter jejuni subsp. jejuni S3 chromosome, complete genomethymidylate synthase ThyX2e-1582.4
NC_009839:30409:319143191432537624Campylobacter jejuni subsp. jejuni 81116, complete genomeprobable thymidylate synthase4e-1581.6
NC_012785:20454:360813608136773693Kosmotoga olearia TBF 19.5.1, complete genomethymidylate synthase, flavin-dependent2e-1479.7
NC_010730:952574:954933954933955907975Sulfurihydrogenibium sp. YO3AOP1, complete genomethymidylate synthase complementing protein ThyX2e-1479.3
NC_015859:952500:976946976946977746801Corynebacterium variabile DSM 44702 chromosome, complete genomeputative thymidylate synthase5e-1478.2
NC_012590:2117027:214794921479492148659711Corynebacterium aurimucosum ATCC 700975, complete genomethymidylate synthase2e-1272.8
NC_017362:1512959:151477515147751515401627Helicobacter pylori Lithuania75 chromosome, complete genomeFAD-dependent thymidylate synthase4e-1168.6
NC_008701:1582839:158547515854751586209735Pyrobaculum islandicum DSM 4184, complete genomethymidylate synthase, flavin-dependent3e-1065.5
NC_013921:1977444:1981197198119719827171521Thermoanaerobacter italicus Ab9 chromosome, complete genomethymidylate synthase complementing protein ThyX6e-1064.7
NC_014209:1910109:1913807191380719153271521Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,thymidylate synthase complementing protein ThyX1e-0963.9
NC_015732:30472:483234832349183861Spirochaeta caldaria DSM 7334 chromosome, complete genomeThymidylate synthase thyX9e-1063.9
NC_015555:327562:3808913808913824081518Thermoanaerobacterium xylanolyticum LX-11 chromosome, completethymidylate synthase complementing protein ThyX9e-1063.9
NC_018643:937486:952807952807953754948Alpha proteobacterium HIMB5 chromosome, complete genomethymidylate synthase, flavin-dependent8e-1063.9
NC_015578:298989:322141322141322983843Treponema primitia ZAS-2 chromosome, complete genomethymidylate synthase, flavin-dependent2e-0963.2
NC_015958:2251619:2251619225161922531391521Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomethymidylate synthase complementing protein ThyX2e-0962.8
NC_015953:5444572:545061554506155451352738Streptomyces sp. SirexAA-E chromosome, complete genomethymidylate synthase, flavin-dependent2e-0859.3
NC_019970:439969:4514684514684529851518Thermoanaerobacterium thermosaccharolyticum M0795, complete genomealternative thymidylate synthase4e-0858.5
NC_020911:1549065:1571958157195815730611104Octadecabacter antarcticus 307, complete genomethymidylate synthase9e-0857.4
NC_007205:1:92679267103011035Candidatus Pelagibacter ubique HTCC1062, complete genomethymidylate synthase9e-0857.4
NC_015387:1344467:135879213587921359643852Marinithermus hydrothermalis DSM 14884 chromosome, complete genomeThymidylate synthase thyX8e-0857.4
NC_018750:5828000:583628358362835837023741Streptomyces venezuelae ATCC 10712, complete genomeThymidylate synthase thyX2e-0756.6
NC_013009:122000:141801141801142676876Neorickettsia risticii str. Illinois, complete genomethymidylate synthase, flavin-dependent8e-0754.3
NC_005295:1146500:115303111530311153888858Ehrlichia ruminantium str. Welgevonden, complete genomethymidylate synthase2e-0653.1
NC_007798:112840:130622130622131500879Neorickettsia sennetsu str. Miyayama, complete genomethymidylate synthase, flavin-dependent2e-0653.1
NC_006831:1112000:112112711211271122020894Ehrlichia ruminantium str. Gardel, complete genomethymidylate synthase2e-0653.1
NC_006832:1125000:113163011316301132526897Ehrlichia ruminantium str. Welgevonden, complete genomethymidylate synthase2e-0653.1