Pre_GI: BLASTP Hits

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Query: NC_015425:198315:215434 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 215434, End: 216549, Length: 1116

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:196257:2108032108032118821080Clostridium novyi NT, complete genomeMembrane-associated protein3e-117421
NC_020291:166500:1680001680001691001101Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomePilT/Pin/TRAM domain-containing protein3e-88325
NC_009617:163466:1663881663881674881101Clostridium beijerinckii NCIMB 8052 chromosome, complete genomePilT domain-containing protein5e-88325
NC_010723:223935:2257042257042267981095Clostridium botulinum E3 str. Alaska E43, complete genomepin/tram domain protein5e-86318
NC_010674:222016:2237852237852248791095Clostridium botulinum B str. Eklund 17B, complete genomepin/tram domain protein6e-85314
NC_014393:4482896:4526109452610945272001092Clostridium cellulovorans 743B chromosome, complete genomePilT protein domain-containing protein2e-82306
NC_008262:2598920:2644741264474126458471107Clostridium perfringens SM101, complete genomePIN/TRAM domain protein1e-80300
NC_019970:336472:3535113535113546141104Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeintegral membrane protein (PIN domain superfamily)4e-79295
NC_009633:4563877:4606339460633946074421104Alkaliphilus metalliredigens QYMF chromosome, complete genomePilT domain-containing protein8e-77287
NC_002570:126500:1401361401361412241089Bacillus halodurans C-125, complete genomehypothetical protein8e-74277
NC_013316:1:4786147861489551095Clostridium difficile R20291, complete genomehypothetical protein8e-73274
NC_014378:131810:1520641520641531881125Acetohalobium arabaticum DSM 5501 chromosome, complete genomePilT protein domain protein4e-71268
NC_017208:64500:1037621037621048651104Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein1e-70267
NC_018704:81733:1132481132481143571110Amphibacillus xylanus NBRC 15112, complete genomehypothetical protein3e-70265
NC_011899:86800:1099341099341110281095Halothermothrix orenii H 168, complete genomePilT protein domain protein2e-69263
NC_019903:421000:4336704336704348391170Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,integral membrane protein7e-69261
NC_015275:3594890:3629710362971036307651056Clostridium lentocellum DSM 5427 chromosome, complete genomePilT protein domain protein1e-67257
NC_007503:2098980:2098980209898021000651086Carboxydothermus hydrogenoformans Z-2901, complete genomePIN/TRAM domain protein1e-66253
NC_012673:1600242:1600978160097816020421065Exiguobacterium sp. AT1b, complete genomePilT protein domain protein5e-65248
NC_010382:4479464:4490259449025944913441086Lysinibacillus sphaericus C3-41, complete genomehypothetical protein8e-65247
NC_011297:1296968:130221213022121303021810Dictyoglomus thermophilum H-6-12, complete genomepin/tram domain protein1e-61237
NC_013792:33893:3389333893349811089Bacillus pseudofirmus OF4 plasmid pBpOF4-01, complete sequencehypothetical protein2e-61236
NC_014960:3375807:3400231340023134013131083Anaerolinea thermophila UNI-1, complete genomehypothetical protein1e-60234
NC_010999:2450974:2466321246632124674361116Lactobacillus casei, complete genomeIntegral membrane protein, PIN and TRAM domains3e-59229
NC_016148:951446:9713159713159724631149Thermovirga lienii DSM 17291 chromosome, complete genometwitching motility protein PilT2e-58226
NC_004461:277291:2891102891102901681059Staphylococcus epidermidis ATCC 12228, complete genomehypothetical protein2e-44180
NC_017243:3093393:311148631114863112148663Brachyspira intermedia PWS/A chromosome, complete genomeIntegral membrane protein2e-43176
NC_014221:2392150:239910923991092400083975Truepera radiovictrix DSM 17093 chromosome, complete genomePilT protein domain protein2e-40166
NC_007516:774489:8108998108998120561158Synechococcus sp. CC9605, complete genomeNucleotide binding protein, PINc2e-36153
NC_011295:779569:7860367860367870401005Coprothermobacter proteolyticus DSM 5265, complete genomeconserved membrane protein, contains PIN domain2e-30133