Pre_GI: BLASTP Hits

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Query: NC_015425:198315:213664 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 213664, End: 214728, Length: 1065

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:196257:2089922089922100591068Clostridium novyi NT, complete genomeDomain of unknown function DUF147 family protein0657
NC_011837:165913:1873961873961884781083Clostridium kluyveri NBRC 12016, complete genomeDNA integrity scanning protein DisA6e-166583
NC_021182:4602683:4602683460268346037561074Clostridium pasteurianum BC1, complete genomeputative nucleic-acid-binding protein (contains the HHH domain)4e-165580
NC_009697:3711692:3711692371169237127531062Clostridium botulinum A str. ATCC 19397 chromosome, completeDNA integrity scanning protein DisA4e-164577
NC_009495:3735703:3735703373570337367641062Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeDNA integrity scanning protein DisA4e-164577
NC_015687:3326461:3326461332646133275341074Clostridium acetobutylicum DSM 1731 chromosome, complete genomeDNA integrity scanning protein DisA6e-157553
NC_003030:3324834:3324834332483433259071074Clostridium acetobutylicum ATCC 824, complete genomePredicted nucleic-acid-binding protein protein, containing HHH domain, YACK B.subtilis ortholog6e-157553
NC_020291:166500:1666811666811677631083Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeDNA integrity scanning protein DisA2e-153541
NC_008262:2598920:2646594264659426476581065Clostridium perfringens SM101, complete genomeDomain of unknown function DUF147 family1e-152539
NC_010674:222016:2220162220162230801065Clostridium botulinum B str. Eklund 17B, complete genomeDNA integrity scanning protein DisA4e-151534
NC_010723:223935:2239352239352249991065Clostridium botulinum E3 str. Alaska E43, complete genomeDNA integrity scanning protein DisA1e-150532
NC_009617:163466:1650811650811661451065Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeDNA integrity scanning protein DisA2e-150532
NC_014393:4482896:4527953452795345290261074Clostridium cellulovorans 743B chromosome, complete genomeDNA integrity scanning, DisA, linker region1e-142506
NC_015573:3167207:3166125316612531672101086Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomeDNA integrity scanning protein disA1e-119429
NC_014654:2138794:2138794213879421398731080Halanaerobium sp. 'sapolanicus' chromosome, complete genomeDNA integrity scanning, DisA, linker region3e-117422
NC_007503:2098980:2101163210116321022211059Carboxydothermus hydrogenoformans Z-2901, complete genomeputative DNA-binding protein4e-115414
NC_011899:86800:1080911080911091701080Halothermothrix orenii H 168, complete genomepredicted nucleic-acid-binding protein (contains the HHH domain)7e-115414
NC_009012:2100000:2105320210532021064021083Clostridium thermocellum ATCC 27405, complete genomeprotein of unknown function DUF1476e-113407
NC_014378:131810:1503181503181514391122Acetohalobium arabaticum DSM 5501 chromosome, complete genomeDNA integrity scanning, DisA, linker region2e-110399
NC_013316:1:4670246702477721071Clostridium difficile R20291, complete genomeputative DNA-binding protein6e-110397
NC_017208:64500:1025281025281036011074Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeDNA integrity scanning protein DisA6e-103374
NC_002570:126500:1389041389041399771074Bacillus halodurans C-125, complete genomehypothetical protein9e-101367
NC_011297:1296968:1303079130307913041341056Dictyoglomus thermophilum H-6-12, complete genomeDNA integrity scanning protein DisA6e-84311
NC_015514:3911655:3931993393199339330631071Cellulomonas fimi ATCC 484 chromosome, complete genomeDNA integrity scanning, DisA, linker region1e-81303
NC_015499:352934:3540863540863551741089Thermodesulfobium narugense DSM 14796 chromosome, complete genomeDNA integrity scanning, DisA, linker region6e-80298
NC_008268:4669530:4693804469380446948891086Rhodococcus sp. RHA1, complete genomehypothetical protein5e-79295