Pre_GI: BLASTP Hits

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Query: NC_015425:198315:200437 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 200437, End: 200931, Length: 495

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014328:180482:182633182633183142510Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative anaerobic ribonucleoside-triphosphate reductase activating protein1e-38159
NC_020291:79502:941829418294691510Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein NrdG6e-34142
NC_014614:1090000:109602810960281096540513Clostridium sticklandii, complete genomeanaerobic ribonucleotide reductase activating protein9e-33139
NC_014220:837926:847150847150847641492Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein2e-30131
NC_004663:2509433:251430925143092514803495Bacteroides thetaiotaomicron VPI-5482, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein3e-30130
NC_021171:608315:628611628611629099489Bacillus sp. 1NLA3E, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein9e-30129
NC_009089:117980:140393140393140932540Clostridium difficile 630, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein1e-29128
NC_013316:120759:142198142198142737540Clostridium difficile R20291, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein1e-29128
NC_016023:1923170:192802619280261928502477Bacillus coagulans 36D1 chromosome, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein4e-29127
NC_014828:2657623:267336426733642673885522Ethanoligenens harbinense YUAN-3 chromosome, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein5e-29126
NC_012814:1494331:152164215216421522391750Bifidobacterium animalis subsp. lactis Bl-04, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein4e-28124
NC_012815:1494263:152136015213601522109750Bifidobacterium animalis subsp. lactis DSM 10140, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein4e-28124
NC_011835:625472:652571652571653320750Bifidobacterium animalis subsp. lactis AD011 chromosome, completeanaerobic ribonucleoside-triphosphate reductase activating protein4e-28124
NC_014633:837588:882099882099882599501Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceribonucleoside-triphosphate reductase class III activase subunit4e-28124
NC_017214:191791:218888218888219637750Bifidobacterium animalis subsp. lactis BB-12 chromosome, completeAnaerobic ribonucleoside-triphosphate reductase activating protein4e-28124
NC_017215:1499179:152627615262761527025750Bifidobacterium animalis subsp. lactis CNCM I-2494 chromosome,[Formate-C-acetyltransferase]-activating enzyme4e-28124
NC_017216:1494190:152128715212871522036750Bifidobacterium animalis subsp. lactis BLC1, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein4e-28124
NC_017217:1499832:152692915269291527678750Bifidobacterium animalis subsp. lactis V9 chromosome, completeanaerobic ribonucleoside-triphosphate reductase activating protein4e-28124
NC_006322:3628143:364951636495163650028513Bacillus licheniformis ATCC 14580, complete genomehypothetical protein8e-28122
NC_006270:3627974:364934736493473649859513Bacillus licheniformis ATCC 14580, complete genomeiron-binding, putative oxidoreductase1e-27122
NC_015514:3911655:391673339167333917350618Cellulomonas fimi ATCC 484 chromosome, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein7e-27119
NC_015697:321311:322213322213322791579Lactobacillus reuteri SD2112 chromosome, complete genomepyruvate formate-lyase activating enzyme2e-25114
NC_009443:1996812:201924120192412019798558Streptococcus suis 98HAH33, complete genomeorganic radical activating protein2e-23108
NC_012924:1997052:201948520194852020042558Streptococcus suis SC84, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein2e-23108
NC_012926:2047303:206981220698122070369558Streptococcus suis BM407 chromosome, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein2e-23108
NC_002950:1334500:133506413350641335555492Porphyromonas gingivalis W83, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein2e-23107
NC_015571:1265121:126734712673471267838492Porphyromonas gingivalis TDC60, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein2e-23107
NC_010729:1549744:154974415497441550247504Porphyromonas gingivalis ATCC 33277, complete genomeputative anaerobic ribonucleoside-triphosphate reductase activating protein5e-23107
NC_021175:1973880:199462519946251995224600Streptococcus oligofermentans AS 1.3089, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein3e-22104
NC_012673:77610:887168871689174459Exiguobacterium sp. AT1b, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein4e-22103
NC_013895:605488:622812622812623603792Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completeanaerobic ribonucleoside-triphosphate reductase activating protein2e-21101
NC_019757:3010262:302396830239683024591624Cylindrospermum stagnale PCC 7417, complete genomeorganic radical activating enzyme1e-2099.4
NC_013170:277321:298574298574299122549Cryptobacterium curtum DSM 15641, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein9e-2199.4
NC_015389:809474:811765811765812319555Coriobacterium glomerans PW2 chromosome, complete genomeribonucleoside-triphosphate reductase class III activase subunit8e-2199.4
NC_014829:4511738:451786345178634518372510Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein2e-2098.6
NC_014628:501755:507748507748508086339Paenibacillus polymyxa SC2 plasmid pSC2, complete sequenceAnaerobic ribonucleoside-triphosphate reductase activating protein3e-2097.8
NC_012913:56258:595905959060117528Aggregatibacter aphrophilus NJ8700, complete genomehypothetical protein2e-1995.1
NC_012658:1052957:106572210657221066315594Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative anaerobic ribonucleoside-triphosphate reductase activating protein2e-1995.1
NC_008095:3371673:339190633919063392514609Myxococcus xanthus DK 1622, complete genomeputative radical SAM domain protein5e-1993.6
NC_009699:1122000:112656011265601127153594Clostridium botulinum F str. Langeland chromosome, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein5e-1993.6
NC_015942:2293455:229345522934552294039585Acidithiobacillus ferrivorans SS3 chromosome, complete genomeradical SAM domain-containing protein7e-1889.7
NC_014960:1835697:184783718478371848409573Anaerolinea thermophila UNI-1, complete genomehypothetical protein8e-1786.3
NC_014830:3387479:339491033949103395539630Intrasporangium calvum DSM 43043 chromosome, complete genomeRadical SAM domain protein1e-1685.5
NC_020063:4170464:419253241925324193080549Enterobacteriaceae bacterium strain FGI 57, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein1e-1685.5
NC_008758:143907:174395174395175015621Polaromonas naphthalenivorans CJ2 plasmid pPNAP02, completeRadical SAM domain protein1e-1685.5
NC_016818:546805:568232568232568696465Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completeanaerobic ribonucleoside-triphosphate reductase activating protein5e-1683.6
NC_014960:2141345:214753721475372148160624Anaerolinea thermophila UNI-1, complete genomehypothetical protein6e-1373.6
NC_015555:49842:739707397074698729Thermoanaerobacterium xylanolyticum LX-11 chromosome, completepyruvate formate-lyase activating enzyme9e-1166.2
NC_005945:3359598:337082333708233371122300Bacillus anthracis str. Sterne, complete genomeadical activating3e-1064.3
NC_014410:51711:749047490475632729Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,pyruvate formate-lyase activating enzyme1e-0962
NC_019970:35985:607916079161519729Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepyruvate formate-lyase 1-activating enzyme1e-0962
NC_014828:1019533:105051310505131051043531Ethanoligenens harbinense YUAN-3 chromosome, complete genomeradical SAM domain-containing protein2e-0962
NC_009831:2045811:204581120458112046551741Shewanella sediminis HAW-EB3, complete genome(Formate-C-acetyltransferase)-activating enzyme6e-0960.1
NC_013714:1521404:154305415430541543935882Bifidobacterium dentium Bd1, complete genomepflA1 Pyruvate formate-lyase activating enzyme2e-0858.5
NC_014614:2500301:252580225258022526560759Clostridium sticklandii, complete genomepyruvate formate lyase activating enzyme 12e-0755.5
NC_014376:317312:336200336200336973774Clostridium saccharolyticum WM1 chromosome, complete genomepyruvate formate-lyase activating enzyme2e-0755.1
NC_004347:3028000:304450830445083045248741Shewanella oneidensis MR-1, complete genomepyruvate formate-lyase 1 activating enzyme2e-0755.1
NC_008618:1206157:122747812274781228356879Bifidobacterium adolescentis ATCC 15703, complete genomepyruvate formate-lyase 1 activating enzyme3e-0754.7
NC_015500:311845:324489324489325265777Treponema brennaborense DSM 12168 chromosome, complete genome(Formate-C-acetyltransferase)-activating enzyme3e-0754.3
NC_010001:3421710:344193634419363442688753Clostridium phytofermentans ISDg, complete genomepyruvate formate-lyase activating enzyme8e-0753.1
NC_015320:273979:281574281574282272699Archaeoglobus veneficus SNP6 chromosome, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein8e-0753.1
NC_016605:233087:236623236623237444822Pediococcus claussenii ATCC BAA-344 chromosome, complete genomepyruvate formate-lyase activating enzyme2e-0652
NC_008463:2467219:250025025002502500888639Pseudomonas aeruginosa UCBPP-PA14, complete genomeputative radical activating enzyme4e-0650.8
NC_009635:518000:537434537434538171738Methanococcus aeolicus Nankai-3 chromosome, complete genomeanaerobic ribonucleoside-triphosphate reductase activating protein6e-0650.1