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Query: NC_015425:1867620:1887215 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 1887215, End: 1887847, Length: 633

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:1631438:164791616479161648512597Clostridium novyi NT, complete genomeuncharacterized membrane protein4e-84310
NC_017295:389500:389635389635390213579Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein5e-40164
NC_015687:389500:389641389641390219579Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein5e-40164
NC_003030:389500:389645389645390223579Clostridium acetobutylicum ATCC 824, complete genomeUncharacterized membrane protein, homolog of YPAA B.subtilis5e-40164
NC_014393:187454:208501208501209106606Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein2e-37155
NC_021182:2422226:242566124256612426251591Clostridium pasteurianum BC1, complete genomehypothetical protein9e-35146
NC_009089:4140764:415671641567164157306591Clostridium difficile 630, complete genomehypothetical protein4e-31134
NC_013316:4018451:403503840350384035655618Clostridium difficile R20291, complete genomehypothetical protein5e-31134
NC_015425:198315:204840204840205409570Clostridium botulinum BKT015925 chromosome, complete genomemembrane protein1e-28126
NC_008593:196257:200097200097200708612Clostridium novyi NT, complete genomeuncharacterized membrane protein8e-28123
NC_018664:2459994:248022024802202480981762Clostridium acidurici 9a chromosome, complete genomehypothetical protein4e-25114
NC_015958:2361551:236511223651122365648537Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehypothetical protein2e-22105
NC_010320:819326:833722833722834249528Thermoanaerobacter sp. X514 chromosome, complete genomehypothetical protein2e-21102
NC_015555:277364:285307285307285807501Thermoanaerobacterium xylanolyticum LX-11 chromosome, completemembrane protein-like protein protein8e-21100
NC_014624:3561756:356274735627473563340594Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein2e-1685.9
NC_009922:490500:501560501560502069510Alkaliphilus oremlandii OhILAs, complete genomemembrane protein5e-1684.3
NC_015759:1117122:113882711388271139444618Weissella koreensis KACC 15510 chromosome, complete genomeintegral membrane protein6e-1270.9
NC_015385:351393:369454369454370110657Treponema succinifaciens DSM 2489 chromosome, complete genomehypothetical protein8e-1167