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Query: NC_015425:1867620:1886290 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 1886290, End: 1886847, Length: 558

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:1631438:164702516470251647543519Clostridium novyi NT, complete genomehypothetical protein6e-70263
NC_015634:2779392:278022627802262780744519Bacillus coagulans 2-6 chromosome, complete genomehypothetical protein5e-39160
NC_014376:1217000:123133712313371231891555Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein7e-35146
NC_010723:2873886:287388628738862874431546Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein9e-29126
NC_010674:3049500:304961730496173050162546Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein1e-28125
NC_014376:1217000:123761812376181238154537Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein3e-26117
NC_012984:3077004:308577030857703086318549Lactobacillus plantarum JDM1, complete genomeintegral membrane protein1e-1892.8
NC_014654:2138794:215951221595122160054543Halanaerobium sp. 'sapolanicus' chromosome, complete genomesignal transduction histidine kinase, LytS1e-1582.8
NC_010003:2029416:203586220358622036398537Petrotoga mobilis SJ95, complete genomehypothetical protein4e-1064.3
NC_016630:28410:319073190732641735Filifactor alocis ATCC 35896 chromosome, complete genomehypothetical protein7e-0753.5