Pre_GI: BLASTP Hits

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Query: NC_014560:518582:537827 Helicobacter pylori SJM180 chromosome, complete genome

Start: 537827, End: 538681, Length: 855

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014256:683384:703259703259704110852Helicobacter pylori B8 chromosome, complete genomechitin synthase regulatory factor 38e-137486
NC_017354:848500:867792867792868646855Helicobacter pylori 52 chromosome, complete genomehypothetical protein3e-137488
NC_017368:852490:871433871433872278846Helicobacter pylori F16, complete genomehypothetical protein2e-92339
NC_017365:848500:868017868017868580564Helicobacter pylori F30, complete genomehypothetical protein5e-56218
NC_017357:495213:497189497189498043855Helicobacter pylori 908 chromosome, complete genomehypothetical protein6e-131466
NC_017359:813500:832281832281833111831Helicobacter pylori Sat464 chromosome, complete genomehypothetical protein1e-78293
NC_017372:855384:874421874421875275855Helicobacter pylori India7 chromosome, complete genomehypothetical protein5e-134477
NC_017365:848500:868577868577868864288Helicobacter pylori F30, complete genomehypothetical protein1e-26120
NC_017375:872478:891400891400892293894Helicobacter pylori 83 chromosome, complete genomeSel1 repeat superfamily protein3e-92338
NC_017360:1052473:107170210717021072574873Helicobacter pylori 35A chromosome, complete genomeSel1 repeat superfamily protein3e-92338