Pre_GI: BLASTP Hits

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Query: NC_014560:518582:536850 Helicobacter pylori SJM180 chromosome, complete genome

Start: 536850, End: 537200, Length: 351

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017376:538000:539368539368539730363Helicobacter pylori SNT49 chromosome, complete genomecag pathogenicity island protein Epsilon2e-51200
NC_017372:855384:873432873432873833402Helicobacter pylori India7 chromosome, complete genomecag pathogenicity island protein Epsilon3e-50196
NC_017379:505350:505350505350505679330Helicobacter pylori Puno135 chromosome, complete genomecag pathogenicity island protein Epsilon1e-48191
NC_011333:514464:514464514464514715252Helicobacter pylori G27 chromosome, complete genomehypothetical protein5e-39159
NC_017362:506950:506950506950507195246Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein5e-38155
NC_017357:495213:498805498805499464660Helicobacter pylori 908 chromosome, complete genomecag island protein4e-29126
NC_017374:498588:497936497936498595660Helicobacter pylori 2017 chromosome, complete genomecag island protein4e-29126
NC_017381:500699:500047500047500706660Helicobacter pylori 2018 chromosome, complete genomecag pathogenicity island protein4e-29126
NC_000921:511642:510990510990511649660Helicobacter pylori J99, complete genomecag island protein4e-29126
NC_017063:800156:800156800156800599444Helicobacter pylori ELS37 chromosome, complete genomecag island protein7e-29125
NC_017371:530673:530021530021530680660Helicobacter pylori Gambia94/24 chromosome, complete genomecag island protein3e-28124
NC_018939:547793:547793547793548035243Helicobacter pylori 26695 chromosome, complete genomecag pathogenicity island protein Epsilon1e-2098.6
NC_000915:547783:547783547783548025243Helicobacter pylori 26695, complete genome1e-2098.6
NC_018939:547793:548035548035548151117Helicobacter pylori 26695 chromosome, complete genomecag island protein1e-0858.9