Pre_GI: BLASTP Hits

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Query: NC_014560:518582:534886 Helicobacter pylori SJM180 chromosome, complete genome

Start: 534886, End: 535395, Length: 510

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017374:498588:500043500043500552510Helicobacter pylori 2017 chromosome, complete genomecag island protein1e-83308
NC_017381:500699:502154502154502663510Helicobacter pylori 2018 chromosome, complete genomecagGamma protein1e-83308
NC_018939:547793:549599549599550108510Helicobacter pylori 26695 chromosome, complete genomecag pathogenicity island protein (cag4)3e-92337
NC_000915:547783:549589549589550098510Helicobacter pylori 26695, complete genomecag pathogenicity island protein (cag4)3e-92337
NC_017360:1052473:106905110690511069560510Helicobacter pylori 35A chromosome, complete genomecag pathogenicity island protein2e-89327
NC_017354:848500:865080865080865589510Helicobacter pylori 52 chromosome, complete genomecag pathogenicity island protein 41e-90331
NC_017375:872478:888749888749889258510Helicobacter pylori 83 chromosome, complete genomecag pathogenicity island protein8e-89325
NC_017357:495213:500912500912501421510Helicobacter pylori 908 chromosome, complete genomecag island protein1e-83308
NC_014256:683384:700014700014700523510Helicobacter pylori B8 chromosome, complete genomecag pathogenicity island protein gamma2e-91334
NC_017358:563336:564791564791565300510Helicobacter pylori Cuz20 chromosome, complete genomecag pathogenicity island protein (cag4)6e-90329
NC_017063:800156:802047802047802556510Helicobacter pylori ELS37 chromosome, complete genomecag pathogenicity island protein (cag4)1e-86317
NC_017368:852490:868755868755869264510Helicobacter pylori F16, complete genomecag island protein4e-89326
NC_017365:848500:865335865335865844510Helicobacter pylori F30, complete genomecag island protein6e-90329
NC_017366:535188:536643536643537152510Helicobacter pylori F32, complete genomecag island protein2e-86317
NC_017367:562918:564373564373564882510Helicobacter pylori F57, complete genomecag island protein3e-89327
NC_011333:514464:516165516165516674510Helicobacter pylori G27 chromosome, complete genomecag pathogenicity island protein 41e-91335
NC_017371:530673:532128532128532637510Helicobacter pylori Gambia94/24 chromosome, complete genomecag pathogenicity island protein (cag4)6e-84309
NC_008086:513407:515613515613516122510Helicobacter pylori HPAG1, complete genomecag pathogenicity island protein 42e-90331
NC_017372:855384:871478871478871855378Helicobacter pylori India7 chromosome, complete genomecag pathogenicity island protein gamma1e-66251
NC_000921:511642:513097513097513606510Helicobacter pylori J99, complete genomecag island protein9e-83305
NC_017362:506950:508650508650509159510Helicobacter pylori Lithuania75 chromosome, complete genomecag pathogenicity island protein gamma2e-92337
NC_011498:553525:554980554980555489510Helicobacter pylori P12, complete genomecag pathogenicity island protein Gamma1e-92338
NC_014555:502151:503606503606504115510Helicobacter pylori PeCan4 chromosome, complete genomecag pathogenicity island protein (cag4)2e-83307
NC_017378:502806:504261504261504770510Helicobacter pylori Puno120 chromosome, complete genomecag pathogenicity island protein (cag4)2e-89327
NC_017379:505350:507150507150507659510Helicobacter pylori Puno135 chromosome, complete genomecag pathogenicity island protein 43e-88323
NC_017359:813500:829530829530830039510Helicobacter pylori Sat464 chromosome, complete genomecag pathogenicity island protein (cag4)1e-89328
NC_010698:819912:842336842336842716381Helicobacter pylori Shi470, complete genomecag pathogenicity island protein (cag4)9e-63239
NC_017376:538000:541178541178541687510Helicobacter pylori SNT49 chromosome, complete genomecag pathogenicity island protein Gamma4e-94343
NC_017355:493237:495266495266495775510Helicobacter pylori v225d chromosome, complete genomehypothetical protein3e-90330