Pre_GI: BLASTP Hits

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Query: NC_014560:518582:522061 Helicobacter pylori SJM180 chromosome, complete genome

Start: 522061, End: 523668, Length: 1608

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011498:553525:5673055673055689121608Helicobacter pylori P12, complete genomecag pathogenicity island protein W0946
NC_017362:506950:5206675206675222741608Helicobacter pylori Lithuania75 chromosome, complete genomecag pathogenicity island protein W0945
NC_017063:800156:8142198142198158261608Helicobacter pylori ELS37 chromosome, complete genomecag island protein0944
NC_011333:514464:5281235281235297301608Helicobacter pylori G27 chromosome, complete genomecag pathogenicity island protein W0943
NC_018939:547793:5616355616355632421608Helicobacter pylori 26695 chromosome, complete genomecag pathogenicity island protein (cag9)0942
NC_000915:547783:5616255616255632321608Helicobacter pylori 26695, complete genomecag pathogenicity island protein (cag9)0942
NC_017371:530673:5445515445515461581608Helicobacter pylori Gambia94/24 chromosome, complete genomecag pathogenicity island protein W0942
NC_017374:498588:5097095097095113161608Helicobacter pylori 2017 chromosome, complete genomecag pathogenicity island protein0941
NC_017381:500699:5118095118095134161608Helicobacter pylori 2018 chromosome, complete genomecag pathogenicity island protein0941
NC_017354:848500:8520358520358536421608Helicobacter pylori 52 chromosome, complete genomecag pathogenicity island protein W0941
NC_000921:511642:5251695251695267761608Helicobacter pylori J99, complete genomecag island protein0941
NC_017376:538000:5528395528395544461608Helicobacter pylori SNT49 chromosome, complete genomecag pathogenicity island protein W0940
NC_017372:855384:8588348588348604411608Helicobacter pylori India7 chromosome, complete genomecag pathogenicity island protein W0940
NC_017355:493237:5068245068245084311608Helicobacter pylori v225d chromosome, complete genomeCytochrome b0940
NC_017366:535188:5490865490865506931608Helicobacter pylori F32, complete genomecag pathogenicity island protein0939
NC_017367:562918:5762075762075778141608Helicobacter pylori F57, complete genomecag pathogenicity island protein0938
NC_017360:1052473:1056119105611910577261608Helicobacter pylori 35A chromosome, complete genomecag pathogenicity island protein0938
NC_017365:848500:8520208520208536271608Helicobacter pylori F30, complete genomecag pathogenicity island protein0938
NC_017368:852490:8558298558298574361608Helicobacter pylori F16, complete genomecag pathogenicity island protein0937
NC_008086:513407:5277975277975294041608Helicobacter pylori HPAG1, complete genomecag pathogenicity island protein W0937
NC_014256:683384:6868356868356884331599Helicobacter pylori B8 chromosome, complete genomecag pathogenicity island protein W0936
NC_017378:502806:5161875161875177941608Helicobacter pylori Puno120 chromosome, complete genomecag pathogenicity island protein W0934
NC_017375:872478:8758218758218774281608Helicobacter pylori 83 chromosome, complete genomecag pathogenicity island protein0934
NC_017379:505350:5190025190025206091608Helicobacter pylori Puno135 chromosome, complete genomecag pathogenicity island protein W0933
NC_014555:502151:5154105154105170171608Helicobacter pylori PeCan4 chromosome, complete genomecag pathogenicity island protein W0933
NC_017359:813500:8170218170218186281608Helicobacter pylori Sat464 chromosome, complete genomecag pathogenicity island protein (cagW, cag9)0924
NC_010698:819912:8294238294238310301608Helicobacter pylori Shi470, complete genomecag island protein0923
NC_017358:563336:5761255761255777321608Helicobacter pylori Cuz20 chromosome, complete genomecag pathogenicity island protein (cagW, cag9)0921
NC_017357:495213:5111265111265122951170Helicobacter pylori 908 chromosome, complete genomecag pathogenicity island protein0669
NC_017357:495213:510534510534511166633Helicobacter pylori 908 chromosome, complete genomecag pathogenicity island protein7e-74278