Pre_GI: BLASTP Hits

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Query: NC_014560:518582:520261 Helicobacter pylori SJM180 chromosome, complete genome

Start: 520261, End: 520917, Length: 657

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017381:500699:514560514560515216657Helicobacter pylori 2018 chromosome, complete genomecag pathogenicity island protein1e-95349
NC_017374:498588:512460512460513116657Helicobacter pylori 2017 chromosome, complete genomecag pathogenicity island protein1e-95349
NC_017357:495213:513439513439514095657Helicobacter pylori 908 chromosome, complete genomecag pathogenicity island protein1e-95349
NC_000921:511642:527921527921528577657Helicobacter pylori J99, complete genomecag island protein1e-95349
NC_017371:530673:547301547301547957657Helicobacter pylori Gambia94/24 chromosome, complete genomecag island protein2e-95348
NC_017063:800156:816985816985817641657Helicobacter pylori ELS37 chromosome, complete genomecag island protein8e-95346
NC_000915:547783:564381564381565037657Helicobacter pylori 26695, complete genomecag pathogenicity island protein (cag11)2e-94344
NC_018939:547793:564391564391565047657Helicobacter pylori 26695 chromosome, complete genomecag pathogenicity island protein (cag11)2e-94344
NC_017355:493237:509446509446510093648Helicobacter pylori v225d chromosome, complete genomecag pathogenicity island protein (cagU)7e-93339
NC_010698:819912:827737827737828384648Helicobacter pylori Shi470, complete genomecag island protein9e-93339
NC_017368:852490:854149854149854796648Helicobacter pylori F16, complete genomecag pathogenicity island protein2e-92338
NC_017365:848500:850335850335850982648Helicobacter pylori F30, complete genomecag pathogenicity island protein2e-92338
NC_017360:1052473:105443210544321055082651Helicobacter pylori 35A chromosome, complete genomecag pathogenicity island protein2e-92338
NC_017379:505350:521631521631522278648Helicobacter pylori Puno135 chromosome, complete genomecag pathogenicity island protein2e-92338
NC_017366:535188:551732551732552379648Helicobacter pylori F32, complete genomecag pathogenicity island protein4e-92337
NC_014256:683384:685035685035685685651Helicobacter pylori B8 chromosome, complete genomecag pathogenicity island protein U3e-92337
NC_011333:514464:530890530890531540651Helicobacter pylori G27 chromosome, complete genomecag pathogenicity island protein U3e-92337
NC_011498:553525:570070570070570720651Helicobacter pylori P12, complete genomecag pathogenicity island protein U6e-92336
NC_017358:563336:578771578771579418648Helicobacter pylori Cuz20 chromosome, complete genomecag pathogenicity island protein (cagU, cag11)1e-91335
NC_017359:813500:815338815338815985648Helicobacter pylori Sat464 chromosome, complete genomecag pathogenicity island protein (cagU, cag11)2e-91335
NC_017378:502806:518831518831519478648Helicobacter pylori Puno120 chromosome, complete genomecag pathogenicity island protein (cagU, cag11)2e-91335
NC_017367:562918:578847578847579494648Helicobacter pylori F57, complete genomecag pathogenicity island protein2e-91334
NC_017376:538000:555590555590556240651Helicobacter pylori SNT49 chromosome, complete genomecag pathogenicity island protein U6e-91333
NC_014555:502151:518055518055518702648Helicobacter pylori PeCan4 chromosome, complete genomecag pathogenicity island protein (cagU, cag11)5e-91333
NC_017375:872478:874137874137874784648Helicobacter pylori 83 chromosome, complete genomecag pathogenicity island protein4e-91333
NC_017372:855384:857040857040857690651Helicobacter pylori India7 chromosome, complete genomecag pathogenicity island protein (cagU, cag11)4e-91333
NC_017362:506950:523434523434524084651Helicobacter pylori Lithuania75 chromosome, complete genomecag pathogenicity island protein U4e-91333
NC_008086:513407:530565530565531215651Helicobacter pylori HPAG1, complete genomecag pathogenicity island protein U1e-90332
NC_017354:848500:850244850244850891648Helicobacter pylori 52 chromosome, complete genomecag pathogenicity island protein U2e-90331