Pre_GI: BLASTP Hits

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Query: NC_014560:518582:518582 Helicobacter pylori SJM180 chromosome, complete genome

Start: 518582, End: 519181, Length: 600

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017381:500699:516276516276516875600Helicobacter pylori 2018 chromosome, complete genomecag pathogenicity island protein6e-110396
NC_017374:498588:514176514176514775600Helicobacter pylori 2017 chromosome, complete genomecag pathogenicity island protein6e-110396
NC_017357:495213:515155515155515754600Helicobacter pylori 908 chromosome, complete genomecag pathogenicity island protein6e-110396
NC_017371:530673:549037549037549630594Helicobacter pylori Gambia94/24 chromosome, complete genomeCAG pathogenicity island protein S9e-107385
NC_017063:800156:818719818719819318600Helicobacter pylori ELS37 chromosome, complete genomeCAG pathogenicity island protein S9e-106382
NC_017365:848500:848676848676849275600Helicobacter pylori F30, complete genomecag pathogenicity island protein9e-106382
NC_011498:553525:571777571777572376600Helicobacter pylori P12, complete genomecag pathogenicity island protein S8e-106382
NC_017368:852490:852490852490853089600Helicobacter pylori F16, complete genomecag pathogenicity island protein8e-106382
NC_014555:502151:519762519762520361600Helicobacter pylori PeCan4 chromosome, complete genomeCAG pathogenicity island protein 131e-105381
NC_000921:511642:529660529660530259600Helicobacter pylori J99, complete genomecag island protein2e-105381
NC_014256:683384:683384683384683983600Helicobacter pylori B8 chromosome, complete genomecag pathogenicity island protein S3e-105380
NC_017360:1052473:105277610527761053375600Helicobacter pylori 35A chromosome, complete genomeCAG pathogenicity island protein 138e-105379
NC_008086:513407:532270532270532869600Helicobacter pylori HPAG1, complete genomecag pathogenicity island protein S9e-105379
NC_017376:538000:557296557296557895600Helicobacter pylori SNT49 chromosome, complete genomeCAG pathogenicity island protein S9e-105379
NC_017367:562918:580554580554581153600Helicobacter pylori F57, complete genomecag pathogenicity island protein1e-104378
NC_017375:872478:872478872478873077600Helicobacter pylori 83 chromosome, complete genomeCAG pathogenicity island protein 132e-104377
NC_017372:855384:855384855384855983600Helicobacter pylori India7 chromosome, complete genomeCAG pathogenicity island protein 132e-104377
NC_011333:514464:532592532592533191600Helicobacter pylori G27 chromosome, complete genomecag pathogenicity island protein S3e-104377
NC_017379:505350:523338523338523937600Helicobacter pylori Puno135 chromosome, complete genomeCAG pathogenicity island protein S3e-104377
NC_017354:848500:848585848585849184600Helicobacter pylori 52 chromosome, complete genomecag pathogenicity island protein S5e-104376
NC_017366:535188:553434553434554033600Helicobacter pylori F32, complete genomecag pathogenicity island protein6e-104376
NC_010698:819912:826078826078826677600Helicobacter pylori Shi470, complete genomecag pathogenicity island protein S1e-103375
NC_017362:506950:525136525136525735600Helicobacter pylori Lithuania75 chromosome, complete genomeCAG pathogenicity island protein 139e-104375
NC_017359:813500:813679813679814278600Helicobacter pylori Sat464 chromosome, complete genomeCAG pathogenicity island protein 133e-103374
NC_017358:563336:580478580478581077600Helicobacter pylori Cuz20 chromosome, complete genomeCAG pathogenicity island protein 135e-103373
NC_017378:502806:520538520538521137600Helicobacter pylori Puno120 chromosome, complete genomeCAG pathogenicity island protein S5e-103373
NC_018939:547793:566136566136566726591Helicobacter pylori 26695 chromosome, complete genomecag pathogenicity island protein S8e-103372
NC_000915:547783:566126566126566716591Helicobacter pylori 26695, complete genomecag pathogenicity island protein (cag13)8e-103372
NC_017355:493237:511153511153511614462Helicobacter pylori v225d chromosome, complete genomecag pathogenicity island protein2e-82304