Pre_GI: BLASTP Hits

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Query: NC_014560:1366747:1407011 Helicobacter pylori SJM180 chromosome, complete genome

Start: 1407011, End: 1407262, Length: 252

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018939:1044000:105483210548321055083252Helicobacter pylori 26695 chromosome, complete genomehypothetical protein8e-43172
NC_017371:1470582:148000114800011480252252Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein8e-43172
NC_017362:1512959:152281415228141523065252Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein8e-43172
NC_017063:834674:878330878330878581252Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein8e-43172
NC_014256:485969:495486495486495737252Helicobacter pylori B8 chromosome, complete genomehypothetical protein8e-43172
NC_000915:1044000:105481510548151055066252Helicobacter pylori 26695, complete genomehypothetical protein8e-43172
NC_017372:748097:758306758306758557252Helicobacter pylori India7 chromosome, complete genomehypothetical protein7e-36149
NC_017379:996500:102112710211271021378252Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein2e-34144