Some Help

Query: NC_014560:1366747:1403840 Helicobacter pylori SJM180 chromosome, complete genome

Start: 1403840, End: 1404820, Length: 981

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia

SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000921:1007519:1041145104114510421581014Helicobacter pylori J99, complete genomehypothetical protein1e-167589
NC_017371:1470582:1481285148128514822981014Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein4e-167587
NC_014256:485969:4967764967764977891014Helicobacter pylori B8 chromosome, complete genomehypothetical protein4e-165580
NC_000915:1044000:105360010536001054229630Helicobacter pylori 26695, complete genomehypothetical protein8e-113406
NC_017375:77142:816718167182441771Helicobacter pylori 83 chromosome, complete genomehypothetical protein6e-27121
NC_000915:1044000:105437610543761054615240Helicobacter pylori 26695, complete genomehypothetical protein3e-26119
NC_017372:748097:759698759698760345648Helicobacter pylori India7 chromosome, complete genomehypothetical protein4e-1789