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Query: NC_014560:1366747:1396865 Helicobacter pylori SJM180 chromosome, complete genome

Start: 1396865, End: 1397845, Length: 981

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1470582:1488324148832414893761053Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein4e-162570
NC_017372:748097:7661877661877672391053Helicobacter pylori India7 chromosome, complete genomehypothetical protein5e-162570
NC_017063:834674:8695498695498706011053Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein5e-162570
NC_014256:485969:5037915037915048431053Helicobacter pylori B8 chromosome, complete genomehypothetical protein4e-161567
NC_017378:1518529:1538564153856415396281065Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein1e-131469
NC_017375:77142:8808088080891471068Helicobacter pylori 83 chromosome, complete genomehypothetical protein1e-127456
NC_017366:1055319:1073209107320910742761068Helicobacter pylori F32, complete genomehypothetical protein4e-124444
NC_017362:1512959:153013615301361530453318Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein1e-41170
NC_011498:448000:4608104608104618321023Helicobacter pylori P12, complete genomehypothetical protein5e-0858.9
NC_000921:1007519:1022556102255610235721017Helicobacter pylori J99, complete genomehypothetical protein1e-0654.3