Pre_GI: BLASTP Hits

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Query: NC_014560:1366747:1394312 Helicobacter pylori SJM180 chromosome, complete genome

Start: 1394312, End: 1394977, Length: 666

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1470582:149124814912481491913666Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein2e-113407
NC_000921:1007519:1036277103627710372961020Helicobacter pylori J99, complete genomehypothetical protein4e-109393
NC_017063:834674:867011867011867676666Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein7e-109392
NC_014256:485969:506715506715507380666Helicobacter pylori B8 chromosome, complete genomehypothetical protein2e-108391
NC_011498:1391788:141448014144801415145666Helicobacter pylori P12, complete genomehypothetical protein8e-108389
NC_017362:1512959:153707315370731537720648Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein2e-104377
NC_017378:1518529:153593115359311536569639Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein2e-90331
NC_017366:1055319:107078610707861071358573Helicobacter pylori F32, complete genomehypothetical protein8e-74276
NC_017375:77142:910209102091592573Helicobacter pylori 83 chromosome, complete genomehypothetical protein4e-73273
NC_017372:748097:769114769114769677564Helicobacter pylori India7 chromosome, complete genomehypothetical protein7e-72270