Pre_GI: BLASTP Hits

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Query: NC_014560:1366747:1380830 Helicobacter pylori SJM180 chromosome, complete genome

Start: 1380830, End: 1381867, Length: 1038

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011333:1040192:1076345107634510773821038Helicobacter pylori G27 chromosome, complete genomehypothetical protein0657
NC_017358:220900:2578862578862589231038Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein0652
NC_017361:1528239:1558781155878115597881008Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein3e-179627
NC_017375:1498000:1513566151356615146031038Helicobacter pylori 83 chromosome, complete genomehypothetical protein0654
NC_017361:930280:9420959420959431021008Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein3e-179627
NC_014555:1526775:1568164156816415692011038Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein0655
NC_017367:278916:3150093150093160461038Helicobacter pylori F57, complete genomehypothetical protein0642
NC_011498:448000:4608104608104618321023Helicobacter pylori P12, complete genomehypothetical protein2e-1273.6
NC_017376:57500:6887068870699071038Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein0657
NC_010698:870312:8821848821848832211038Helicobacter pylori Shi470, complete genomehypothetical protein0650
NC_000921:1007519:1022556102255610235721017Helicobacter pylori J99, complete genomehypothetical protein2e-1273.6