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Query: NC_014560:1366747:1373302 Helicobacter pylori SJM180 chromosome, complete genome

Start: 1373302, End: 1373415, Length: 114

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014256:485969:5275845275845286571074Helicobacter pylori B8 chromosome, complete genomeXerCD family integrase/recombinase2e-1167.8
NC_011498:448000:4524234524234534961074Helicobacter pylori P12, complete genomeintegrase/recombinase XercD family2e-1167.8
NC_000921:1007519:1055965105596510570381074Helicobacter pylori J99, complete genomeINTEGRASE/RECOMBINASE (XERCD FAMILY)2e-1167.4
NC_017357:973392:990660990660991196537Helicobacter pylori 908 chromosome, complete genomehypothetical protein6e-0959.7
NC_017374:974279:991547991547992083537Helicobacter pylori 2017 chromosome, complete genomeXERCD family protein/integrase/ recombinase6e-0959.7
NC_017381:982216:9995029995021000038537Helicobacter pylori 2018 chromosome, complete genomeintegrase/recombinase6e-0959.7
NC_018939:1044000:1056175105617510572421068Helicobacter pylori 26695 chromosome, complete genomeintegrase/recombinase (xerD)7e-0959.3
NC_000915:1044000:1056158105615810572251068Helicobacter pylori 26695, complete genomeintegrase/recombinase (xerD)7e-0959.3
NC_000921:1007519:104368410436841044679996Helicobacter pylori J99, complete genomeINTEGRASE/RECOMBINASE (XERCD FAMILY)3e-0857.4
NC_014256:485969:4933274933274943941068Helicobacter pylori B8 chromosome, complete genomehypothetical protein3e-0857.4
NC_017371:1470582:1477848147784814789181071Helicobacter pylori Gambia94/24 chromosome, complete genomeintegrase/recombinase (xerD)3e-0857.4
NC_017372:748097:7561247561247571911068Helicobacter pylori India7 chromosome, complete genomeintegrase/recombinase (xerD)3e-0857.4
NC_014560:1366747:1408465140846514095321068Helicobacter pylori SJM180 chromosome, complete genomeintegrase/recombinase (xerD)3e-0857.4
NC_017362:1512959:1520655152065515217221068Helicobacter pylori Lithuania75 chromosome, complete genomeintegrase/recombinase (xerD)3e-0857.4
NC_017063:834674:8796738796738807401068Helicobacter pylori ELS37 chromosome, complete genomeintegrase/recombinase (xerD)7e-0856.2
NC_015674:1605923:160891616089161609266351Helicobacter bizzozeronii CIII-1, complete genomeXerCD family integrase/recombinase5e-0753.1
NC_014555:1526775:1534128153412815351951068Helicobacter pylori PeCan4 chromosome, complete genomeintegrase/recombinase (xerD)2e-0651.2