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Query: NC_014555:47372:66773 Helicobacter pylori PeCan4 chromosome, complete genome

Start: 66773, End: 67360, Length: 588

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from a Peruvian gastric cancer patient. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014560:53750:752797527975866588Helicobacter pylori SJM180 chromosome, complete genomeurease accessory protein / pH-dependent urea-transporter1e-100364
NC_012973:49208:690706907069657588Helicobacter pylori B38 chromosome, complete genomeurease accessory protein UreI3e-99360
NC_018939:53715:747477474775334588Helicobacter pylori 26695 chromosome, complete genomeurease accessory protein UreI3e-99360
NC_000915:53715:747477474775334588Helicobacter pylori 26695, complete genomeurease accessory protein (ureI)3e-99360