Pre_GI: BLASTP Hits

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Query: NC_014555:47372:66259 Helicobacter pylori PeCan4 chromosome, complete genome

Start: 66259, End: 66771, Length: 513

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from a Peruvian gastric cancer patient. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014560:53750:747657476575277513Helicobacter pylori SJM180 chromosome, complete genomeurease accessory protein UreE5e-94342
NC_012973:49208:685566855669068513Helicobacter pylori B38 chromosome, complete genomeurease accessory protein UreE9e-94342
NC_018939:53715:742337423374745513Helicobacter pylori 26695 chromosome, complete genomeurease accessory protein UreE3e-93340
NC_000915:53715:742337423374745513Helicobacter pylori 26695, complete genomeurease accessory protein (ureE)3e-93340
NC_015172:951550:963434963434963883450Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeUrease accessory protein ureE6e-1683.6
NC_011886:404661:415111415111415596486Arthrobacter chlorophenolicus A6, complete genomeUreE urease accessory domain protein7e-0856.6
NC_012803:361127:373782373782374279498Micrococcus luteus NCTC 2665, complete genomeurease accessory protein UreE2e-0651.6
NC_007645:4651532:465153246515324652137606Hahella chejuensis KCTC 2396, complete genomeUrease accessory protein UreE3e-0651.2