Pre_GI: BLASTP Hits

Some Help

Query: NC_014555:47372:59028 Helicobacter pylori PeCan4 chromosome, complete genome

Start: 59028, End: 59288, Length: 261

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from a Peruvian gastric cancer patient. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia



SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010170:4409683:442361844236184423887270Bordetella petrii, complete genomehypothetical protein8e-0649.3
NC_010170:4463000:449303144930314493300270Bordetella petrii, complete genomehypothetical protein8e-0649.3
NC_010002:4572573:460143646014364601705270Delftia acidovorans SPH-1, complete genomehypothetical protein4e-0650.4
NC_018939:53715:670396703967299261Helicobacter pylori 26695 chromosome, complete genomehypothetical protein5e-40162
NC_000915:53715:670396703967299261Helicobacter pylori 26695, complete genomehypothetical protein5e-40162
NC_017375:77142:777277772777855129Helicobacter pylori 83 chromosome, complete genomehypothetical protein9e-1268.9
NC_012973:49208:611196111961379261Helicobacter pylori B38 chromosome, complete genomehypothetical protein1e-39161
NC_014560:53750:675066750667766261Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein1e-42171
NC_017376:57500:593145931459574261Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein2e-38157