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Query: NC_014555:1477934:1498820 Helicobacter pylori PeCan4 chromosome, complete genome

Start: 1498820, End: 1499356, Length: 537

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from a Peruvian gastric cancer patient. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017354:1465925:148679614867961487332537Helicobacter pylori 52 chromosome, complete genomepurine nucleoside phosphorylase3e-97353
NC_017367:1505780:152941515294151529957543Helicobacter pylori F57, complete genomepurine nucleoside phosphorylase2e-95347
NC_008787:1582110:159914615991461599682537Campylobacter jejuni subsp. jejuni 81-176, complete genomehypothetical protein5e-26117
NC_002163:1607360:162454116245411625077537Campylobacter jejuni subsp. jejuni NCTC 11168, complete genomehypothetical protein3e-26117
NC_017279:1603916:162193516219351622471537Campylobacter jejuni subsp. jejuni IA3902 chromosome, completehypothetical protein3e-26117
NC_009707:1811650:182867018286701829206537Campylobacter jejuni subsp. doylei 269.97 chromosome, completehypothetical protein3e-26117
NC_017281:1645903:166392016639201664456537Campylobacter jejuni subsp. jejuni S3 chromosome, complete genomepurine nucleoside phosphorylase (punB)7e-26116
NC_003912:1742370:176038717603871760923537Campylobacter jejuni RM1221, complete genomehypothetical protein7e-26116
NC_014802:1631483:164853016485301649066537Campylobacter jejuni subsp. jejuni ICDCCJ07001 chromosome, completehypothetical protein9e-26116
NC_017280:1584961:160119416011941601730537Campylobacter jejuni subsp. jejuni M1 chromosome, complete genomepurine nucleoside phosphorylase (punB)2e-25115