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Query: NC_012943:3777371 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 3777371, End: 3802949, Length: 25579

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009565:37939763793976381869024715Mycobacterium tuberculosis F11, complete genome037100BLASTN svgBLASTP svg
NC_002755:37737343773734379844824715Mycobacterium tuberculosis CDC1551, complete genome037060BLASTN svgBLASTP svg
NC_002945:37351413735141376077425634Mycobacterium bovis AF2122/97, complete genome037010BLASTN svgBLASTP svg
NC_012207:37669783766978379261425637Mycobacterium bovis BCG str. Tokyo 172, complete genome036980BLASTN svgBLASTP svg
NC_008769:37690653769065379470125637Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome036980BLASTN svgBLASTP svg
NC_015848:38512303851230387671725488Mycobacterium canettii CIPT 140010059, complete genome029900BLASTN svgBLASTP svg
NC_019950:38180003818000384014722148Mycobacterium canettii CIPT 140060008 complete genome026160BLASTN svgBLASTP svg
NC_000962:37815013781501380757326073Mycobacterium tuberculosis H37Rv, complete genome025850BLASTN svgBLASTP svg
NC_009525:37940003794000381625122252Mycobacterium tuberculosis H37Ra, complete genome020170BLASTN svgBLASTP svg
NC_009077:1027357*1027357106455537199Mycobacterium sp. JLS, complete genome1e-61246BLASTN svgBLASTP svg
NC_014168:709036*70903673493125896Segniliparus rotundus DSM 44985 chromosome, complete genome1e-39172BLASTN svgBLASTP svg
NC_002677:49104349104351327322231Mycobacterium leprae TN, complete genome9e-22113BLASTN svgBLASTP svg
NC_008782:2062962*2062962208700324042Acidovorax sp. JS42, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_013947:3785332*3785332384029254961Stackebrandtia nassauensis DSM 44728 chromosome, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_020133:48419324841932485992417993Mycobacterium liflandii 128FXT, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_002755:83139783139785005418658Mycobacterium tuberculosis CDC1551, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_002945:83102983102985365622628Mycobacterium bovis AF2122/97, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_008769:86067086067087969619027Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_009525:83051383051384921918707Mycobacterium tuberculosis H37Ra, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_009565:83307683307685178218707Mycobacterium tuberculosis F11, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_012207:83103083103085360922580Mycobacterium bovis BCG str. Tokyo 172, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_020133:14439341443934146609922166Mycobacterium liflandii 128FXT, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_012725:976819768112016422484Burkholderia glumae BGR1 plasmid bglu_4p, complete sequence1e-0869.9BLASTN svgBLASTP svg
NC_009525:39335673933567395892925363Mycobacterium tuberculosis H37Ra, complete genome5e-0867.9BLASTN svgBLASTP svg