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Query: NC_012943:2707677 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2707677, End: 2734914, Length: 27238

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009565:16886421688642171216323522Mycobacterium tuberculosis F11, complete genome043090BLASTN svgBLASTP svg
NC_009525:16855221685522171115225631Mycobacterium tuberculosis H37Ra, complete genome043060BLASTN svgBLASTP svg
NC_000962:16840051684005170853924535Mycobacterium tuberculosis H37Rv, complete genome043060BLASTN svgBLASTP svg
NC_002755:16841611684161170880524645Mycobacterium tuberculosis CDC1551, complete genome043040BLASTN svgBLASTP svg
NC_015848:17081761708176173271724542Mycobacterium canettii CIPT 140010059, complete genome042690BLASTN svgBLASTP svg
NC_002945:16807511680751170398323233Mycobacterium bovis AF2122/97, complete genome023680BLASTN svgBLASTP svg
NC_008769:17090781709078173231123234Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome023680BLASTN svgBLASTP svg
NC_012207:16819711681971170520423234Mycobacterium bovis BCG str. Tokyo 172, complete genome023680BLASTN svgBLASTP svg
NC_019950:16899101689910171687926970Mycobacterium canettii CIPT 140060008 complete genome023250BLASTN svgBLASTP svg
NC_002944:12854361285436132132435889Mycobacterium avium subsp. paratuberculosis K-10, complete genome02216BLASTN svgBLASTP svg
NC_010612:27776872777687279716619480Mycobacterium marinum M, complete genome0763BLASTN svgBLASTP svg
NC_008268:5781604*5781604581424432641Rhodococcus sp. RHA1, complete genome5e-79303BLASTN svgBLASTP svg
NC_018581:11809511180951122156540615Gordonia sp. KTR9 chromosome, complete genome2e-59238BLASTN svgBLASTP svg
NC_009525:2635792*2635792265864122850Mycobacterium tuberculosis H37Ra, complete genome9e-53216BLASTN svgBLASTP svg
NC_015848:2684275*2684275270528621012Mycobacterium canettii CIPT 140010059, complete genome1e-51212BLASTN svgBLASTP svg
NC_007512:14596851459685148211322429Pelodictyon luteolum DSM 273, complete genome1e-48202BLASTN svgBLASTP svg
NC_011992:19682581968258199851030253Acidovorax ebreus TPSY, complete genome8e-47196BLASTN svgBLASTP svg
NC_013446:26559552655955268195826004Comamonas testosteroni CNB-2, complete genome3e-28135BLASTN svgBLASTP svg
NC_014034:995661*995661102273727077Rhodobacter capsulatus SB1003 chromosome, complete genome4e-24121BLASTN svgBLASTP svg
NC_014100:533322*53332256190028579Caulobacter segnis ATCC 21756 chromosome, complete genome2e-23119BLASTN svgBLASTP svg
NC_015125:24439452443945246359819654Microbacterium testaceum StLB037, complete genome6e-20107BLASTN svgBLASTP svg
NC_011145:49609404960940498025219313Anaeromyxobacter sp. K, complete genome2e-19105BLASTN svgBLASTP svg
NC_000962:32884643288464331029721834Mycobacterium tuberculosis H37Rv, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_002755:32827853282785330371920935Mycobacterium tuberculosis CDC1551, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_002945:32462783246278326609919822Mycobacterium bovis AF2122/97, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_008769:32424533242453326356021108Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_009525:33004563300456332228921834Mycobacterium tuberculosis H37Ra, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_009565:32999373299937332177021834Mycobacterium tuberculosis F11, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_012207:32374403237440325728519846Mycobacterium bovis BCG str. Tokyo 172, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_015848:33437313343731336691823188Mycobacterium canettii CIPT 140010059, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_019950:33064193306419333122724809Mycobacterium canettii CIPT 140060008 complete genome1e-1799.6BLASTN svgBLASTP svg
NC_007760:49111814911181493806026880Anaeromyxobacter dehalogenans 2CP-C, complete genome6e-1797.6BLASTN svgBLASTP svg
NC_011891:315182*31518233809922918Anaeromyxobacter dehalogenans 2CP-1, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_011145:306623*30662333037323751Anaeromyxobacter sp. K, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_009937:1733196*1733196175210518910Azorhizobium caulinodans ORS 571, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_008146:1016446*1016446104459328148Mycobacterium sp. MCS, complete genome6e-1487.7BLASTN svgBLASTP svg
NC_010814:3474856*3474856349401319158Geobacter lovleyi SZ, complete genome9e-1383.8BLASTN svgBLASTP svg
NC_015160:1786350*1786350181459928250Odoribacter splanchnicus DSM 20712 chromosome, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_008702:39280433928043395047222430Azoarcus sp. BH72, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_004463:17725411772541179709924559Bradyrhizobium japonicum USDA 110, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_008702:2942246*2942246296909926854Azoarcus sp. BH72, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_014973:28942482894248291621621969Geobacter sp. M18 chromosome, complete genome5e-0867.9BLASTN svgBLASTP svg
NC_008148:24980002498000255085152852Rubrobacter xylanophilus DSM 9941, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_007517:1468719*1468719150798939271Geobacter metallireducens GS-15, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_002935:1237585*1237585131159974015Corynebacterium diphtheriae NCTC 13129, complete genome3e-0661.9BLASTN svgBLASTP svg