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Query: NC_012943:2103662 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2103662, End: 2127029, Length: 23368

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009565:2306574*2306574233169725124Mycobacterium tuberculosis F11, complete genome014920BLASTN svgBLASTP svg
NC_011896:17160001716000173793921940Mycobacterium leprae Br4923, complete genome4e-104387BLASTN svgBLASTP svg
NC_002677:17160001716000173800622007Mycobacterium leprae TN, complete genome4e-104387BLASTN svgBLASTP svg
NC_000962:18708421870842189534224501Mycobacterium tuberculosis H37Rv, complete genome1e-91345BLASTN svgBLASTP svg
NC_002755:18596301859630187892619297Mycobacterium tuberculosis CDC1551, complete genome1e-91345BLASTN svgBLASTP svg
NC_002945:18562281856228188073824511Mycobacterium bovis AF2122/97, complete genome1e-91345BLASTN svgBLASTP svg
NC_008769:18761091876109190061624508Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome1e-91345BLASTN svgBLASTP svg
NC_009525:18723601872360189686024501Mycobacterium tuberculosis H37Ra, complete genome1e-91345BLASTN svgBLASTP svg
NC_009565:18662141866214189074224529Mycobacterium tuberculosis F11, complete genome1e-91345BLASTN svgBLASTP svg
NC_012207:18480911848091186924521155Mycobacterium bovis BCG str. Tokyo 172, complete genome1e-91345BLASTN svgBLASTP svg
NC_015848:18966601896660192209125432Mycobacterium canettii CIPT 140010059, complete genome1e-91345BLASTN svgBLASTP svg
NC_019950:18708631870863189629425432Mycobacterium canettii CIPT 140060008 complete genome1e-91345BLASTN svgBLASTP svg
NC_020133:77341773419927021930Mycobacterium liflandii 128FXT, complete genome4e-76293BLASTN svgBLASTP svg
NC_010612:103081*10308113565632576Mycobacterium marinum M, complete genome2e-71278BLASTN svgBLASTP svg
NC_015957:61193466119346619590076555Streptomyces violaceusniger Tu 4113 chromosome, complete genome4e-67264BLASTN svgBLASTP svg
NC_008611:2615204*2615204263604620843Mycobacterium ulcerans Agy99, complete genome1e-66262BLASTN svgBLASTP svg
NC_010612:3745332*3745332378131835987Mycobacterium marinum M, complete genome1e-66262BLASTN svgBLASTP svg
NC_020133:2886541*2886541291380027260Mycobacterium liflandii 128FXT, complete genome1e-66262BLASTN svgBLASTP svg
NC_014391:26513152651315269455543241Micromonospora aurantiaca ATCC 27029 chromosome, complete genome2e-62248BLASTN svgBLASTP svg
NC_010612:46795944679594471951939926Mycobacterium marinum M, complete genome1e-57232BLASTN svgBLASTP svg
NC_015957:60295426029542605506325522Streptomyces violaceusniger Tu 4113 chromosome, complete genome1e-51212BLASTN svgBLASTP svg
NC_003155:11378171137817120257364757Streptomyces avermitilis MA-4680, complete genome4e-45190BLASTN svgBLASTP svg
NC_010572:73042907304290735268448395Streptomyces griseus subsp. griseus NBRC 13350, complete genome1e-36163BLASTN svgBLASTP svg
NC_009142:45718894571889461144339555Saccharopolyspora erythraea NRRL 2338, complete genome6e-35157BLASTN svgBLASTP svg
NC_009565:32999373299937332177021834Mycobacterium tuberculosis F11, complete genome2e-31145BLASTN svgBLASTP svg
NC_002755:32827853282785330371920935Mycobacterium tuberculosis CDC1551, complete genome2e-31145BLASTN svgBLASTP svg
NC_002945:32462783246278326609919822Mycobacterium bovis AF2122/97, complete genome1e-29139BLASTN svgBLASTP svg
NC_008769:32424533242453326356021108Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome1e-29139BLASTN svgBLASTP svg
NC_012207:32374403237440325728519846Mycobacterium bovis BCG str. Tokyo 172, complete genome1e-29139BLASTN svgBLASTP svg
NC_009525:33004563300456332228921834Mycobacterium tuberculosis H37Ra, complete genome6e-29137BLASTN svgBLASTP svg
NC_000962:32884643288464331029721834Mycobacterium tuberculosis H37Rv, complete genome6e-29137BLASTN svgBLASTP svg
NC_019950:33064193306419333122724809Mycobacterium canettii CIPT 140060008 complete genome2e-28135BLASTN svgBLASTP svg
NC_015848:33437313343731336691823188Mycobacterium canettii CIPT 140010059, complete genome2e-28135BLASTN svgBLASTP svg
NC_009921:57874375787437580894021504Frankia sp. EAN1pec, complete genome1e-26129BLASTN svgBLASTP svg
NC_015953:58657335865733590682141089Streptomyces sp. SirexAA-E chromosome, complete genome8e-19103BLASTN svgBLASTP svg
NC_015957:45464034546403458592939527Streptomyces violaceusniger Tu 4113 chromosome, complete genome3e-18101BLASTN svgBLASTP svg
NC_015957:45255804525580455677331194Streptomyces violaceusniger Tu 4113 chromosome, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_011896:17319717319719198818792Mycobacterium leprae Br4923, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_008278:2772726*2772726280322330498Frankia alni ACN14a, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_002677:17317017317019196118792Mycobacterium leprae TN, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_010572:75861157586115761955133437Streptomyces griseus subsp. griseus NBRC 13350, complete genome7e-1383.8BLASTN svgBLASTP svg
NC_015957:42928194292819431625023432Streptomyces violaceusniger Tu 4113 chromosome, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_014318:51839755183975520609922125Amycolatopsis mediterranei U32 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_007777:26385802638580267126232683Frankia sp. CcI3, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_015848:48350048350050998826489Mycobacterium canettii CIPT 140010059, complete genome3e-0661.9BLASTN svgBLASTP svg