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Query: NC_012943:1769445 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 1769445, End: 1792770, Length: 23326

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009525:2635792*2635792265864122850Mycobacterium tuberculosis H37Ra, complete genome014080BLASTN svgBLASTP svg
NC_015848:2684275*2684275270528621012Mycobacterium canettii CIPT 140010059, complete genome011480BLASTN svgBLASTP svg
NC_012207:2573562*2573562259732923768Mycobacterium bovis BCG str. Tokyo 172, complete genome04450BLASTN svgBLASTP svg
NC_009525:37940003794000381625122252Mycobacterium tuberculosis H37Ra, complete genome02688BLASTN svgBLASTP svg
NC_000962:37815013781501380757326073Mycobacterium tuberculosis H37Rv, complete genome02688BLASTN svgBLASTP svg
NC_002755:31109293110929312975718829Mycobacterium tuberculosis CDC1551, complete genome02686BLASTN svgBLASTP svg
NC_002945:30733703073370309459921230Mycobacterium bovis AF2122/97, complete genome02686BLASTN svgBLASTP svg
NC_008769:30702663070266308959919334Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome02686BLASTN svgBLASTP svg
NC_009525:31287863128786314904720262Mycobacterium tuberculosis H37Ra, complete genome02686BLASTN svgBLASTP svg
NC_009565:31280943128094314823720144Mycobacterium tuberculosis F11, complete genome02686BLASTN svgBLASTP svg
NC_009565:34857723485772350477419003Mycobacterium tuberculosis F11, complete genome02686BLASTN svgBLASTP svg
NC_012207:30630393063039308477921741Mycobacterium bovis BCG str. Tokyo 172, complete genome02686BLASTN svgBLASTP svg
NC_000962:31168183116818313633319516Mycobacterium tuberculosis H37Rv, complete genome02686BLASTN svgBLASTP svg
NC_002755:47287247287249645723586Mycobacterium tuberculosis CDC1551, complete genome02678BLASTN svgBLASTP svg
NC_010612:4501414*4501414452499223579Mycobacterium marinum M, complete genome01637BLASTN svgBLASTP svg
NC_009077:2308634*2308634235649847865Mycobacterium sp. JLS, complete genome0775BLASTN svgBLASTP svg
NC_000962:16840051684005170853924535Mycobacterium tuberculosis H37Rv, complete genome8e-53216BLASTN svgBLASTP svg
NC_002755:16841611684161170880524645Mycobacterium tuberculosis CDC1551, complete genome8e-53216BLASTN svgBLASTP svg
NC_009525:16855221685522171115225631Mycobacterium tuberculosis H37Ra, complete genome8e-53216BLASTN svgBLASTP svg
NC_009565:16886421688642171216323522Mycobacterium tuberculosis F11, complete genome8e-53216BLASTN svgBLASTP svg
NC_015848:17081761708176173271724542Mycobacterium canettii CIPT 140010059, complete genome8e-53216BLASTN svgBLASTP svg
NC_019950:16899101689910171687926970Mycobacterium canettii CIPT 140060008 complete genome8e-53216BLASTN svgBLASTP svg
NC_009525:34849243484924350559920676Mycobacterium tuberculosis H37Ra, complete genome6e-29137BLASTN svgBLASTP svg
NC_002755:34655823465582349023924658Mycobacterium tuberculosis CDC1551, complete genome6e-29137BLASTN svgBLASTP svg
NC_000962:34740003474000349418120182Mycobacterium tuberculosis H37Rv, complete genome6e-29137BLASTN svgBLASTP svg
NC_002945:34293153429315345013820824Mycobacterium bovis AF2122/97, complete genome2e-28135BLASTN svgBLASTP svg
NC_008769:34272543427254344807620823Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome2e-28135BLASTN svgBLASTP svg
NC_012207:34211443421144344072619583Mycobacterium bovis BCG str. Tokyo 172, complete genome2e-28135BLASTN svgBLASTP svg
NC_011896:332939*33293935403321095Mycobacterium leprae Br4923, complete genome6e-26127BLASTN svgBLASTP svg
NC_002677:332923*33292335401721095Mycobacterium leprae TN, complete genome6e-26127BLASTN svgBLASTP svg
NC_010612:53011355301135532701825884Mycobacterium marinum M, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_020133:49110444911044493609925056Mycobacterium liflandii 128FXT, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_015957:88452748845274887561630343Streptomyces violaceusniger Tu 4113 chromosome, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_014974:758129*75812978338525257Thermus scotoductus SA-01 chromosome, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_010612:44002604400260442326723008Mycobacterium marinum M, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_006087:1483761*1483761150739223632Leifsonia xyli subsp. xyli str. CTCB07, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_013235:3812838*3812838384142328586Nakamurella multipartita DSM 44233, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_013235:13544431354443137485420412Nakamurella multipartita DSM 44233, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_008435:1215437*1215437131209196655Rhodopseudomonas palustris BisA53, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_014815:841484*84148489809956616Micromonospora sp. L5 chromosome, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_015966:2841420*2841420286298221563Rhodothermus marinus SG0.5JP17-172 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_014933:510164*51016459333883175Bacteroides helcogenes P 36-108 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_014814:2588628*2588628264757658949Mycobacterium sp. Spyr1 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_012721:25561602556160260386447705Burkholderia glumae BGR1 chromosome 2, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_008752:32176953217695323954921855Acidovorax avenae subsp. citrulli AAC00-1, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_008752:29369332936933297832941397Acidovorax avenae subsp. citrulli AAC00-1, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_010125:10517351051735108259930865Gluconacetobacter diazotrophicus PAl 5, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_021177:78704647870464790349933036Streptomyces fulvissimus DSM 40593, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_012207:83103083103085360922580Mycobacterium bovis BCG str. Tokyo 172, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_011896:13800001380000140588025881Mycobacterium leprae Br4923, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_002945:83102983102985365622628Mycobacterium bovis AF2122/97, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_002677:13800001380000140585225853Mycobacterium leprae TN, complete genome3e-0661.9BLASTN svgBLASTP svg