Pre_GI: BLASTP Hits

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Query: NC_012943:3777371:3802086 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 3802086, End: 3802949, Length: 864

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008769:3769065:379383837938383794701864Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeCyclopropane-fatty-acyl-phospholipid synthase 1 cmaA11e-162572
NC_012207:3766978:379175137917513792614864Mycobacterium bovis BCG str. Tokyo 172, complete genomecyclopropane-fatty-acyl-phospholipid synthase 11e-162572
NC_019950:3818000:383537738353773836240864Mycobacterium canettii CIPT 140060008 complete genomeCyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1)1e-162572
NC_002945:3735141:375991137599113760774864Mycobacterium bovis AF2122/97, complete genomecyclopropane-fatty-acyl-phospholipid synthase 1 CMAA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1)1e-162572
NC_015848:3851230:387490438749043875767864Mycobacterium canettii CIPT 140010059, complete genomecyclopropane-fatty-acyl-phospholipid synthase 1 CMAA12e-159561
NC_009077:1027357:105679010567901057716927Mycobacterium sp. JLS, complete genomeCyclopropane-fatty-acyl-phospholipid synthase3e-116417
NC_014168:709036:721011721011721877867Segniliparus rotundus DSM 44985 chromosome, complete genomecyclopropane-fatty-acyl-phospholipid synthase3e-93341
NC_009077:1027357:105571510557151056683969Mycobacterium sp. JLS, complete genomeCyclopropane-fatty-acyl-phospholipid synthase9e-82303
NC_002944:4446083:445264144526414453540900Mycobacterium avium subsp. paratuberculosis K-10, complete genomeCmaA21e-74279
NC_009256:2945059:2949521294952129507411221Burkholderia vietnamiensis G4 chromosome 1, complete sequencecyclopropane-fatty-acyl-phospholipid synthase1e-43176
NC_012856:798922:8141478141478153671221Ralstonia pickettii 12D chromosome 1, complete genomeCyclopropane-fatty-acyl-phospholipid synthase8e-42170
NC_021184:1257722:1279832127983212810401209Desulfotomaculum gibsoniae DSM 7213, complete genomemethyltransferase, cyclopropane fatty acid synthase3e-40165
NC_016626:1592781:1606303160630316075081206Burkholderia sp. YI23 plasmid byi_1p, complete sequencecyclopropane fatty acid synthase family protein2e-37155
NC_011333:1040192:1042313104231310434821170Helicobacter pylori G27 chromosome, complete genomecyclopropane fatty acid synthase4e-37155
NC_013894:672840:6758226758226770241203Thermocrinis albus DSM 14484 chromosome, complete genomeCyclopropane-fatty-acyl-phospholipid synthase7e-37154
NC_010520:725312:7450847450847462621179Clostridium botulinum A3 str. Loch Maree, complete genomecyclopropane-fatty-acyl-phospholipid synthase7e-37154
NC_010002:2518599:2520777252077725220211245Delftia acidovorans SPH-1, complete genomeCyclopropane-fatty-acyl-phospholipid synthase1e-36153
NC_015563:4911188:4928979492897949302231245Delftia sp. Cs1-4 chromosome, complete genomeCyclopropane-fatty-acyl-phospholipid synthase1e-36153
NC_008593:1513107:1535649153564915368241176Clostridium novyi NT, complete genomecyclopropane fatty acid synthase family protein6e-36151
NC_020207:1795993:1795993179599317971591167Enterococcus faecium NRRL B-2354, complete genomeCyclopropane-fatty-acyl-phospholipid synthase1e-35150
NC_008529:1265958:1272730127273012739111182Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, completeCyclopropane fatty acid synthase related methyltransferase1e-35150
NC_008054:1255219:1259758125975812609391182Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completeCyclopropane-fatty-acyl-phospholipid synthase9e-36150
NC_017161:775610:7782857782857794721188Hydrogenobacter thermophilus TK-6 chromosome, complete genomecyclopropane-fatty-acyl-phospholipid synthase3e-35148
NC_013799:775619:7782947782947794811188Hydrogenobacter thermophilus TK-6, complete genomecyclopropane-fatty-acyl-phospholipid synthase3e-35148
NC_015387:261799:2649422649422662461305Marinithermus hydrothermalis DSM 14884 chromosome, complete genomeCyclopropane-fatty-acyl-phospholipid synthase2e-34145
NC_004668:191732:1969831969831981491167Enterococcus faecalis V583, complete genomecyclopropane-fatty-acyl-phospholipid synthase5e-34145
NC_014006:850763:9083969083969096371242Sphingobium japonicum UT26S chromosome 1, complete genomecyclopropane-fatty-acyl-phospholipid synthase6e-34144
NC_008786:557314:5573145573145586541341Verminephrobacter eiseniae EF01-2, complete genomeCyclopropane-fatty-acyl-phospholipid synthase2e-33142
NC_017316:157254:1618481618481631161269Enterococcus faecalis OG1RF chromosome, complete genomecyclopropane-fatty-acyl-phospholipid synthase2e-33142
NC_012724:1914740:1934231193423119354271197Burkholderia glumae BGR1 chromosome 1, complete genomeProbable cyclopropane-fatty-acyl-phospholipid synthase protein5e-33141
NC_010322:6037566:6043981604398160451651185Pseudomonas putida GB-1 chromosome, complete genomecyclopropane-fatty-acyl-phospholipid synthase2e-32139
NC_015733:5909821:5911402591140259125861185Pseudomonas putida S16 chromosome, complete genomecyclopropane-fatty-acyl-phospholipid synthase3e-32138
NC_015422:2806832:2841069284106928424241356Alicycliphilus denitrificans K601 chromosome, complete genomeCyclopropane-fatty-acyl-phospholipid synthase5e-32138
NC_009138:2242470:2255218225521822565401323Herminiimonas arsenicoxydans, complete genomeputative Cyclopropane-fatty-acyl-phospholipid synthase1e-31137
NC_017986:2687588:2687588268758826888441257Pseudomonas putida ND6 chromosome, complete genomecyclopropane-fatty-acyl-phospholipid synthase3e-31135
NC_013446:2164974:2168194216819421693871194Comamonas testosteroni CNB-2, complete genomeCyclopropane-fatty-acyl-phospholipid synthase3e-31135
NC_018720:2039000:2053991205399120552801290Bifidobacterium asteroides PRL2011 chromosome, complete genomecyclopropane-fatty-acyl-phospholipid synthase9e-31134
NC_010067:1507823:1511386151138615125341149Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein9e-31134
NC_013282:2026083:2072793207279320740641272Cronobacter turicensis, complete genomeCyclopropane-fatty-acyl-phospholipid synthase1e-30134
NC_020260:1993344:1993344199334419944921149Cronobacter sakazakii Sp291, complete genomecyclopropane-fatty-acyl-phospholipid synthase2e-30133
NC_009778:1956225:1956225195622519575171293Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein2e-30133
NC_018750:3141196:3151229315122931525301302Streptomyces venezuelae ATCC 10712, complete genomeCyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_003198:1621347:1621347162134716224951149Salmonella enterica subsp. enterica serovar Typhi str. CT18,cyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_003197:1471349:1504235150423515053831149Salmonella typhimurium LT2, complete genomecyclopropane fatty acyl phospholipid synthase3e-30132
NC_011149:1710601:1710601171060117117491149Salmonella enterica subsp. enterica serovar Agona str. SL483,cyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_011094:1435347:1468149146814914692971149Salmonella enterica subsp. enterica serovar Schwarzengrund strcyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_011205:1852665:1852665185266518538131149Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853cyclopropane fatty acyl phospholipid synthase3e-30132
NC_011274:1763676:1763676176367617648241149Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91cyclopropane fatty acyl phospholipid synthase3e-30132
NC_011294:1723852:1723852172385217250001149Salmonella enterica subsp. enterica serovar Enteritidis strcyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_012125:2360815:2360815236081523619631149Salmonella enterica subsp. enterica serovar Paratyphi C straincyclopropane fatty acyl phospholipid synthase3e-30132
NC_016831:1236786:1269608126960812707561149Salmonella enterica subsp. enterica serovar Gallinarum/pullorumcyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_011080:1470794:1503675150367515048231149Salmonella enterica subsp. enterica serovar Newport str. SL254,cyclopropane-fatty-acyl-phospholipid synthase2e-30132
NC_010102:1616530:1616530161653016176781149Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein2e-30132
NC_011147:1502096:1502096150209615032441149Salmonella enterica subsp. enterica serovar Paratyphi A strcyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_006511:1506915:1506915150691515080631149Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCCcyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_016863:1429516:1462402146240214635501149Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1cyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_016860:1469066:1501922150192215030701149Salmonella enterica subsp. enterica serovar Typhimurium strcyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_016856:1481325:1514211151421115153591149Salmonella enterica subsp. enterica serovar Typhimurium str. 14028Scyclopropane-fatty-acyl-phospholipid synthase3e-30132
NC_014733:1223359:1252608125260812537861179Methylovorus sp. MP688 chromosome, complete genomecyclopropane-fatty-acyl-phospholipid synthase1e-29130
NC_014666:3311893:3318981331898133202311251Frankia sp. EuI1c chromosome, complete genomeCyclopropane-fatty-acyl-phospholipid synthase2e-29129
NC_007775:2546833:2552549255254925536881140Synechococcus sp. JA-3-3Ab, complete genomecyclopropane-fatty-acyl-phospholipid synthase5e-29128
NC_013131:5226919:5243091524309152444191329Catenulispora acidiphila DSM 44928, complete genomeCyclopropane-fatty-acyl-phospholipid synthase7e-29127
NC_007517:2451547:2475128247512824764351308Geobacter metallireducens GS-15, complete genomeCyclopropane-fatty-acyl-phospholipid synthase3e-28125
NC_002932:1851070:1866939186693918680811143Chlorobium tepidum TLS, complete genomecyclopropane-fatty-acyl-phospholipid synthase4e-28125
NC_008343:1548020:1550876155087615521351260Granulibacter bethesdensis CGDNIH1, complete genomecyclopropane-fatty-acyl-phospholipid synthase5e-28124
NC_020209:47504:1202821202821215531272Pseudomonas poae RE*1-1-14, complete genomecyclopropane-fatty-acyl-phospholipid synthase8e-27120
NC_019940:389979:4141624141624153641203Thioflavicoccus mobilis 8321 chromosome, complete genomemethyltransferase, cyclopropane fatty acid synthase4e-26118
NC_015559:2434000:2434310243431024355301221Marinomonas posidonica IVIA-Po-181 chromosome, complete genomeCyclopropane-fatty-acyl-phospholipid synthase1e-25117
NC_008027:5842740:586141858614185862302885Pseudomonas entomophila L48, complete genomeCyclopropane-fatty-acyl-phospholipid synthase2e-24113
NC_013131:4525075:4525075452507545263611287Catenulispora acidiphila DSM 44928, complete genomeCyclopropane-fatty-acyl-phospholipid synthase1e-23110
NC_008782:3110744:3136322313632231375421221Acidovorax sp. JS42, complete genomeCyclopropane-fatty-acyl-phospholipid synthase1e-22107
NC_013720:5769910:5802955580295558040881134Pirellula staleyi DSM 6068, complete genomeCyclopropane-fatty-acyl-phospholipid synthase2e-22106
NC_016002:2534516:2535256253525625364641209Pseudogulbenkiania sp. NH8B, complete genomecyclopropane-fatty-acyl-phospholipid synthase1e-21103
NC_012731:600518:6633446633446645641221Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomeputative cyclopropane-fatty-acyl-phospholipid synthase1e-20100
NC_011886:2369980:2383634238363423850041371Arthrobacter chlorophenolicus A6, complete genomeCyclopropane-fatty-acyl-phospholipid synthase5e-2098.2
NC_007509:71954:7085770857719571101Burkholderia sp. 383 chromosome 3, complete sequenceCyclopropane-fatty-acyl-phospholipid synthase9e-2097.4
NC_014623:3503218:3516339351633935173431005Stigmatella aurantiaca DW4/3-1 chromosome, complete genomesphingolipid c9-methyltransferase-like protein5e-1995.1
NC_015138:3927411:3945818394581839468761059Acidovorax avenae subsp. avenae ATCC 19860 chromosome, completecyclopropane-fatty-acyl-phospholipid synthase2e-1686.7
NC_014654:221707:2285772285772296051029Halanaerobium sp. 'sapolanicus' chromosome, complete genomeMethyltransferase type 112e-1686.7
NC_015677:2715912:2721127272112727222811155Ramlibacter tataouinensis TTB310 chromosome, complete genomecyclopropane-fatty-acyl-phospholipid synthase4e-1582
NC_014973:4630132:4662732466273246639071176Geobacter sp. M18 chromosome, complete genomeCyclopropane-fatty-acyl-phospholipid synthase2e-1479.7