Pre_GI: BLASTP Hits

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Query: NC_012943:3777371:3796165 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 3796165, End: 3798360, Length: 2196

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002755:3773734:3792396379239637947232328Mycobacterium tuberculosis CDC1551, complete genomePE_PGRS family protein1e-49198
NC_009565:3793976:3812770381277038149652196Mycobacterium tuberculosis F11, complete genomePE-PGRS family protein1e-49198
NC_016768:3774105:3792899379289937950942196Mycobacterium tuberculosis KZN 4207 chromosome, complete genomePE-PGRS family protein1e-49198
NC_000962:3781501:3801653380165338038482196Mycobacterium tuberculosis H37Rv, complete genomePE-PGRS FAMILY PROTEIN1e-49198
NC_009525:3794000:3810776381077638125241749Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein2e-49198
NC_012207:3766978:3785773378577337880252253Mycobacterium bovis BCG str. Tokyo 172, complete genomePE-PGRS family protein2e-49197
NC_008769:3769065:3787860378786037901122253Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomePE-PGRS family protein2e-49197
NC_002945:3735141:3753936375393637561852250Mycobacterium bovis AF2122/97, complete genomePE-PGRS family protein2e-49197
NC_016804:3753243:3767225376722537694772253Mycobacterium bovis BCG str. Mexico chromosome, complete genomePE PGRS family protein2e-49197
NC_017026:3754000:377091037709103771389480Mycobacterium tuberculosis RGTB327 chromosome, complete genomePE-PGRS family protein6e-49196
NC_002945:2757821:2771504277150427730331530Mycobacterium bovis AF2122/97, complete genomehypothetical protein6e-25116
NC_019950:2830682:2840852284085228458344983Mycobacterium canettii CIPT 140060008 complete genomeConserved protein of unknown function, PE-PGRS family protein PE_PGRS542e-24115
NC_015848:2859145:2869315286931528742974983Mycobacterium canettii CIPT 140010059, complete genomePE-PGRS family protein1e-24115
NC_009525:2802987:2813222281322228182044983Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein1e-24115
NC_000962:2791019:2801254280125428062364983Mycobacterium tuberculosis H37Rv, complete genomePE-PGRS FAMILY PROTEIN1e-24115
NC_002755:2788000:2796742279674228017394998Mycobacterium tuberculosis CDC1551, complete genomePE_PGRS family protein1e-24115
NC_008769:2754828:2768605276860527700321428Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomePE-PGRS family protein9e-25115
NC_012207:2747599:2761378276137827628051428Mycobacterium bovis BCG str. Tokyo 172, complete genomePE-PGRS family protein9e-25115
NC_016804:2735897:2747970274797027493971428Mycobacterium bovis BCG str. Mexico chromosome, complete genomePE-PGRS family protein9e-25115
NC_009565:2806000:281872728187272819545819Mycobacterium tuberculosis F11, complete genomePE-PGRS family protein7e-23109
NC_009525:3933567:3949108394910839512612154Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein4e-22107
NC_010612:5403000:5410995541099554137272733Mycobacterium marinum M, complete genomePE-PGRS family protein6e-21103
NC_016768:3296478:3315569331556933183702802Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein6e-21103
NC_012943:3299744:3318835331883533216362802Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePE-PGRS family protein6e-21103
NC_020133:5020500:5028630502863050313532724Mycobacterium liflandii 128FXT, complete genomePE-PGRS family protein6e-21103
NC_020133:942375:9423759423759441201746Mycobacterium liflandii 128FXT, complete genomePE-PGRS family protein2e-20101
NC_010612:6113155:6120939612093961252944356Mycobacterium marinum M, complete genomePE-PGRS family protein2e-1997.8
NC_017026:3894000:3909070390907039103891320Mycobacterium tuberculosis RGTB327 chromosome, complete genomePE-PGRS family protein3e-1997.8
NC_015848:1647523:1659310165931016623303021Mycobacterium canettii CIPT 140010059, complete genomePE-PGRS family protein3e-1997.8
NC_010612:5626259:5639613563961356433683756Mycobacterium marinum M, complete genomePE-PGRS family protein1e-1895.5
NC_009565:1629780:1640600164060016428132214Mycobacterium tuberculosis F11, complete genomePE-PGRS family protein1e-1895.5
NC_016768:2764000:2771960277196027741762217Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein2e-1894.7
NC_012943:3299744:3315516331551633168891374Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePE-PGRS family protein3e-1894.4
NC_009565:1098847:1098847109884711002201374Mycobacterium tuberculosis F11, complete genomePE-PGRS family protein3e-1894.4
NC_016768:2764000:2775550277555027797764227Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein3e-1894.4
NC_016768:3296478:3312205331220533136231419Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein3e-1894.4
NC_002945:1621765:1632588163258816349752388Mycobacterium bovis AF2122/97, complete genomePE-PGRS family protein5e-1893.6
NC_002945:1621765:1626985162698516312114227Mycobacterium bovis AF2122/97, complete genomePE-PGRS family protein7e-1893.2
NC_009565:1629780:1635000163500016392234224Mycobacterium tuberculosis F11, complete genomePE-PGRS family protein1e-1792.4
NC_000962:1095078:1095078109507810964511374Mycobacterium tuberculosis H37Rv, complete genomePE-PGRS FAMILY PROTEIN1e-1792.4
NC_009525:1096386:1096386109638610977591374Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein1e-1792.4
NC_012207:1097228:1097228109722810986011374Mycobacterium bovis BCG str. Tokyo 172, complete genomePE-PGRS family protein1e-1792.4
NC_008769:1125567:1125567112556711269401374Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomePE-PGRS family protein1e-1792.4
NC_016804:1095846:1095846109584610972191374Mycobacterium bovis BCG str. Mexico chromosome, complete genomePE-PGRS family protein1e-1792.4
NC_002945:1095337:1095529109552910969021374Mycobacterium bovis AF2122/97, complete genomePE-PGRS family protein9e-1892.4
NC_017026:3894000:3915130391513039161881059Mycobacterium tuberculosis RGTB327 chromosome, complete genomePE-PGRS family protein1e-1792
NC_016804:2735897:2738974273897427405571584Mycobacterium bovis BCG str. Mexico chromosome, complete genomePE-PGRS family protein1e-1792
NC_008769:2754828:2759609275960927611921584Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomePE-PGRS family protein1e-1792
NC_012207:2747599:2752380275238027539631584Mycobacterium bovis BCG str. Tokyo 172, complete genomePE-PGRS family protein1e-1792
NC_009525:3933567:3939682393968239443194638Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein2e-1792
NC_009565:2806000:2809407280940728107021296Mycobacterium tuberculosis F11, complete genomePE-PGRS family protein2e-1791.3
NC_020133:4841932:4857957485795748599241968Mycobacterium liflandii 128FXT, complete genomePE-PGRS family protein2e-1791.3
NC_015848:2859145:2859145285914528612292085Mycobacterium canettii CIPT 140010059, complete genomePE-PGRS family protein3e-1790.9
NC_019950:2830682:2830682283068228327662085Mycobacterium canettii CIPT 140060008 complete genomeConserved protein of unknown function, PE-PGRS family protein3e-1790.9
NC_017026:2786000:2788929278892927910132085Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein4e-1790.5
NC_009525:2802987:2807269280726928093532085Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein4e-1790.5
NC_002755:2788000:2790789279078927928732085Mycobacterium tuberculosis CDC1551, complete genomePE_PGRS family protein4e-1790.5
NC_000962:2791019:2795301279530127973852085Mycobacterium tuberculosis H37Rv, complete genomePE-PGRS FAMILY PROTEIN4e-1790.5
NC_010612:6385520:6388395638839563956937299Mycobacterium marinum M, complete genomePE-PGRS family protein4e-1790.5
NC_002945:2757821:276356627635662764186621Mycobacterium bovis AF2122/97, complete genomehypothetical protein5e-1790.1
NC_009525:3933567:3955294395529439589293636Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein6e-1789.7
NC_015848:2859145:2861559286155928654673909Mycobacterium canettii CIPT 140010059, complete genomePE-PGRS family protein1e-1689
NC_019950:2830682:2833096283309628369803885Mycobacterium canettii CIPT 140060008 complete genomeConserved protein of unknown function, PE-PGRS family protein1e-1689
NC_010612:5403000:5408042540804254107742733Mycobacterium marinum M, complete genomePE-PGRS family protein, PE_PGRS9_31e-1688.6
NC_020133:5965500:5972633597263359781105478Mycobacterium liflandii 128FXT, complete genomePE-PGRS family protein3e-1584.7
NC_012943:3299744:3317611331761133186181008Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePE-PGRS family protein5e-1583.6
NC_016768:3296478:3314345331434533153521008Mycobacterium tuberculosis KZN 4207 chromosome, complete genomePE-PGRS family protein5e-1583.6
NC_017026:3894000:3900446390044639021281683Mycobacterium tuberculosis RGTB327 chromosome, complete genomePE-PGRS family protein1e-1482.4
NC_015848:1647523:1653707165370716579334227Mycobacterium canettii CIPT 140010059, complete genomePE-PGRS family protein2e-1481.6
NC_002755:1095105:1095105109510510965351431Mycobacterium tuberculosis CDC1551, complete genomePE_PGRS family protein2e-1378.2
NC_010612:4400260:4401186440118644032372052Mycobacterium marinum M, complete genomePE-PGRS family protein3e-1377.4
NC_017026:1095753:1095753109575310971291377Mycobacterium tuberculosis RGTB327 chromosome, complete genomePE-PGRS family protein6e-1273.2
NC_020133:1443934:1451027145102714522381212Mycobacterium liflandii 128FXT, complete genomePE-PGRS family protein1e-1172.8
NC_010612:5301135:5307272530727253131965925Mycobacterium marinum M, complete genomePE-PGRS family protein2e-1171.6
NC_002755:831397:835179835179835697519Mycobacterium tuberculosis CDC1551, complete genomePE_PGRS family protein7e-1169.7
NC_008769:860670:864455864455864973519Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomePE-PGRS family protein7e-1169.7
NC_009565:833076:836859836859837377519Mycobacterium tuberculosis F11, complete genomePE-PGRS family protein7e-1169.7
NC_012207:831030:834815834815835333519Mycobacterium bovis BCG str. Tokyo 172, complete genomePE-PGRS family protein7e-1169.7
NC_002945:831029:834814834814835332519Mycobacterium bovis AF2122/97, complete genomePE-PGRS family protein7e-1169.7
NC_009525:830513:834296834296834814519Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein7e-1169.7
NC_012943:830000:833990833990834508519Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePE-PGRS family protein7e-1169.7
NC_016768:830000:833994833994834512519Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein7e-1169.7
NC_016804:831500:834734834734835252519Mycobacterium bovis BCG str. Mexico chromosome, complete genomePE PGRS family protein7e-1169.7
NC_017026:829444:833487833487834005519Mycobacterium tuberculosis RGTB327 chromosome, complete genomePE-PGRS family protein7e-1169.7
NC_020133:4911044:492389649238964924432537Mycobacterium liflandii 128FXT, complete genome7e-1066.6
NC_020133:5020500:503853150385315039034504Mycobacterium liflandii 128FXT, complete genome2e-0965.1
NC_009525:3933567:3935246393524639393914146Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein3e-0964.3
NC_016804:2560000:2574129257412925753701242Mycobacterium bovis BCG str. Mexico chromosome, complete genomePE-PGRS family protein4e-0963.9
NC_012207:2573562:2587536258753625887771242Mycobacterium bovis BCG str. Tokyo 172, complete genomePE-PGRS family protein4e-0963.9
NC_010612:2215724:2224183222418322298075625Mycobacterium marinum M, complete genomePE-PGRS family protein8e-0963.2
NC_012207:831030:8375268375268399192394Mycobacterium bovis BCG str. Tokyo 172, complete genomePE-PGRS family protein2e-0861.6
NC_008769:860670:8671668671668695592394Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomePE-PGRS family protein2e-0861.6
NC_016804:831500:8374458374458398382394Mycobacterium bovis BCG str. Mexico chromosome, complete genomePE-PGRS family protein2e-0861.6
NC_002945:831029:8375258375258399182394Mycobacterium bovis AF2122/97, complete genomePE-PGRS family protein2e-0861.6
NC_010612:5403000:5418899541889954214122514Mycobacterium marinum M, complete genomePE-PGRS family protein3e-0861.2
NC_009525:830513:8370078370078393582352Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein3e-0861.2
NC_002755:831397:8378908378908402412352Mycobacterium tuberculosis CDC1551, complete genomePE_PGRS family protein3e-0861.2
NC_009565:833076:8395708395708419212352Mycobacterium tuberculosis F11, complete genomePE-PGRS family protein3e-0861.2
NC_012943:830000:8367018367018390522352Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePE-PGRS family protein3e-0861.2
NC_016768:830000:8367058367058390562352Mycobacterium tuberculosis KZN 4207 chromosome, complete genomePE-PGRS family protein3e-0861.2
NC_010612:957786:9627049627049690126309Mycobacterium marinum M, complete genomePE-PGRS family protein3e-0757.8
NC_020133:1443934:1448452144845214496511200Mycobacterium liflandii 128FXT, complete genomePE-PGRS family protein4e-0757.4
NC_017904:4742775:475786647578664758165300Mycobacterium sp. MOTT36Y chromosome, complete genomePE family protein5e-0757