Pre_GI: BLASTP Hits

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Query: NC_012943:3777371:3795235 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 3795235, End: 3795975, Length: 741

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:3753243:376635837663583767035678Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transposase4e-121434
NC_002755:3773734:379166137916613792338678Mycobacterium tuberculosis CDC1551, complete genomeIS1560 transposase4e-121434
NC_000962:3781501:380078638007863801463678Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE TRANSPOSASE4e-121434
NC_009525:3794000:380990938099093810586678Mycobacterium tuberculosis H37Ra, complete genomeputative transposase4e-121434
NC_012207:3766978:378490637849063785583678Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transposase4e-121434
NC_009565:3793976:381190338119033812580678Mycobacterium tuberculosis F11, complete genometransposase4e-121434
NC_002945:3735141:375306937530693753746678Mycobacterium bovis AF2122/97, complete genometransposase4e-121434
NC_008769:3769065:378699337869933787670678Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transposase4e-121434
NC_016768:3774105:379203237920323792709678Mycobacterium tuberculosis KZN 4207 chromosome, complete genometransposase4e-121434
NC_017026:3754000:376997937699793770812834Mycobacterium tuberculosis RGTB327 chromosome, complete genometransposase9e-95346
NC_010424:697187:7288687288687302621395Candidatus Desulforudis audaxviator MP104C, complete genomeputative methyl-accepting chemotaxis sensory transducer3e-39162
NC_010424:697187:7285027285027306642163Candidatus Desulforudis audaxviator MP104C, complete genome3e-39162
NC_009454:1389974:1399721139972114010731353Pelotomaculum thermopropionicum SI, complete genomehypothetical protein2e-37155
NC_019897:2004050:2004050200405020054231374Thermobacillus composti KWC4 chromosome, complete genometransposase family protein1e-32139
NC_019897:700332:7094287094287108011374Thermobacillus composti KWC4 chromosome, complete genometransposase family protein1e-32139
NC_019897:329945:3682403682403696131374Thermobacillus composti KWC4 chromosome, complete genometransposase family protein1e-32139
NC_003047:2798367:2802678280267828040121335Sinorhizobium meliloti 1021, complete genomePUTATIVE TRANSPOSASE FOR ISRM17 PROTEIN2e-1686.3
NC_003047:3360000:3375747337574733770811335Sinorhizobium meliloti 1021, complete genomePUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ISRM172e-1686.3
NC_002678:5020000:503753650375365038411876Mesorhizobium loti MAFF303099, complete genometransposase4e-1685.1
NC_008740:1357312:1373584137358413749241341Marinobacter aquaeolei VT8, complete genometransposase, IS4 family protein1e-1170.5
NC_008786:557314:5744265744265759131488Verminephrobacter eiseniae EF01-2, complete genometransposase, IS4 family protein3e-0858.9
NC_009428:807577:811821811821812762942Rhodobacter sphaeroides ATCC 17025 chromosome, complete genometransposase, IS4 family protein3e-0858.9
NC_003296:673790:7201307201307214521323Ralstonia solanacearum GMI1000 plasmid pGMI1000MP, completeISRSO9-TRANSPOSASE PROTEIN4e-0858.5
NC_003295:3688000:3695703369570336970251323Ralstonia solanacearum GMI1000, complete genomeISRSO9-TRANSPOSASE PROTEIN4e-0858.5
NC_003296:168506:1791651791651804871323Ralstonia solanacearum GMI1000 plasmid pGMI1000MP, completeISRSO9-TRANSPOSASE PROTEIN4e-0858.5
NC_014722:1552454:1558846155884615601681323Burkholderia rhizoxinica HKI 454, complete genometransposase4e-0858.5
NC_007489:42500:555995559956489891Rhodobacter sphaeroides 2.4.1 plasmid C, complete sequence6e-0857.8
NC_015510:4065753:4077741407774140790721332Haliscomenobacter hydrossis DSM 1100 chromosome, complete genometransposase IS4 family protein1e-0757
NC_009943:1637582:1645605164560516469571353Candidatus Desulfococcus oleovorans Hxd3, complete genometransposase IS4 family protein1e-0756.6
NC_008760:27967:3581035810370901281Polaromonas naphthalenivorans CJ2 plasmid pPNAP04, completetransposase, IS4 family protein8e-0754.3
NC_014502:113839:1181351181351195771443Cyanothece sp. PCC 7822 plasmid Cy782203, complete sequencetransposase1e-0653.9
NC_015422:2326942:2343034234303423443891356Alicycliphilus denitrificans K601 chromosome, complete genometransposase IS4 family protein2e-0653.1
NC_017267:4232771:4245567424556742469281362Xanthomonas oryzae pv. oryzicola BLS256 chromosome, completetransposase2e-0653.1
NC_008740:1635137:1640698164069816420801383Marinobacter aquaeolei VT8, complete genometransposase, IS4 family protein6e-0651.6
NC_015634:2779392:2791571279157127931181548Bacillus coagulans 2-6 chromosome, complete genometransposase IS4 family protein9e-0650.8