Pre_GI: BLASTP Hits

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Query: NC_012943:3777371:3794529 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 3794529, End: 3795308, Length: 780

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3754000:376934837693483770052705Mycobacterium tuberculosis RGTB327 chromosome, complete genometransposase5e-93340
NC_002945:3735141:375237537523753753079705Mycobacterium bovis AF2122/97, complete genometransposase5e-93340
NC_009525:3794000:380921538092153809919705Mycobacterium tuberculosis H37Ra, complete genomeputative transposase5e-93340
NC_012207:3766978:378421237842123784916705Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transposase5e-93340
NC_000962:3781501:380009238000923800796705Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE TRANSPOSASE5e-93340
NC_002755:3773734:379096737909673791671705Mycobacterium tuberculosis CDC1551, complete genomeIS1560 transposase5e-93340
NC_008769:3769065:378629937862993787003705Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transposase5e-93340
NC_009565:3793976:381120938112093811913705Mycobacterium tuberculosis F11, complete genometransposase5e-93340
NC_016768:3774105:379133837913383792042705Mycobacterium tuberculosis KZN 4207 chromosome, complete genometransposase5e-93340
NC_016804:3753243:376566437656643766368705Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transposase5e-93340
NC_009454:1389974:1399721139972114010731353Pelotomaculum thermopropionicum SI, complete genomehypothetical protein2e-39162
NC_019897:329945:3682403682403696131374Thermobacillus composti KWC4 chromosome, complete genometransposase family protein8e-33140
NC_019897:700332:7094287094287108011374Thermobacillus composti KWC4 chromosome, complete genometransposase family protein8e-33140
NC_019897:2004050:2004050200405020054231374Thermobacillus composti KWC4 chromosome, complete genometransposase family protein8e-33140
NC_010424:697187:7288687288687302621395Candidatus Desulforudis audaxviator MP104C, complete genomeputative methyl-accepting chemotaxis sensory transducer6e-31134
NC_010424:697187:7285027285027306642163Candidatus Desulforudis audaxviator MP104C, complete genome8e-31134
NC_010424:448865:461551461551462291741Candidatus Desulforudis audaxviator MP104C, complete genomehypothetical protein6e-30130
NC_010424:214640:225739225739226218480Candidatus Desulforudis audaxviator MP104C, complete genome2e-1893.2
NC_008740:1357312:1373584137358413749241341Marinobacter aquaeolei VT8, complete genometransposase, IS4 family protein4e-0755.5