Pre_GI: BLASTP Hits

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Query: NC_012943:3777371:3793755 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 3793755, End: 3794147, Length: 393

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002755:3773734:379011837901183790513396Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein1e-57221
NC_008769:3769065:378545037854503785842393Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein1e-57221
NC_009525:3794000:380836638083663808758393Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein1e-57221
NC_012207:3766978:378336337833633783755393Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein1e-57221
NC_002945:3735141:375152637515263751918393Mycobacterium bovis AF2122/97, complete genomehypothetical protein1e-57221
NC_009565:3793976:381036038103603810752393Mycobacterium tuberculosis F11, complete genomehypothetical protein1e-57221
NC_000962:3781501:379924337992433799635393Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein1e-57221
NC_016768:3774105:379048937904893790881393Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein1e-57221
NC_016804:3753243:376481537648153765207393Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein1e-57221
NC_017026:3754000:376849937684993768891393Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein1e-57221
NC_019950:3818000:383100738310073831402396Mycobacterium canettii CIPT 140060008 complete genomeConserved protein of unknown function with PIN domain, possible toxin4e-44176
NC_015848:3851230:386902238690223869405384Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein2e-43174
NC_019673:7797666:781901078190107819408399Saccharothrix espanaensis DSM 44229 complete genomehypothetical protein1e-1375.1
NC_010572:2216309:222803322280332228467435Streptomyces griseus subsp. griseus NBRC 13350, complete genomehypothetical protein3e-1270.5
NC_016943:3037382:305112030511203051509390Blastococcus saxobsidens DD2, complete genomePIN domain protein, Putative toxin of TAS system3e-0857.4