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Query: NC_012943:3777371:3790682 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 3790682, End: 3790963, Length: 282

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002945:3735141:3746896374689637487011806Mycobacterium bovis AF2122/97, complete genome1-deoxy-D-xylulose-5-phosphate synthase1e-21101
NC_019673:6778401:6798338679833868000741737Saccharothrix espanaensis DSM 44229 complete genome1-deoxy-D-xylulose-5-phosphate synthase1e-1065.1
NC_014218:882118:9007839007839026511869Arcanobacterium haemolyticum DSM 20595 chromosome, complete genomedeoxyxylulose-5-phosphate synthase4e-0857
NC_015953:5908467:5926148592614859280641917Streptomyces sp. SirexAA-E chromosome, complete genomedeoxyxylulose-5-phosphate synthase2e-0754.7
NC_016114:1435436:1435436143543614373491914Streptomyces flavogriseus ATCC 33331 chromosome, complete genomedeoxyxylulose-5-phosphate synthase4e-0753.5
NC_013422:1755875:1802616180261618045471932Halothiobacillus neapolitanus c2, complete genomedeoxyxylulose-5-phosphate synthase1e-0652
NC_010572:1748668:1748668174866817505811914Streptomyces griseus subsp. griseus NBRC 13350, complete genomeputative 1-deoxy-D-xylulose 5-phosphate synthase3e-0650.4
NC_021177:6662668:6679999667999966819121914Streptomyces fulvissimus DSM 40593, complete genomeDXS 1-deoxy-D-xylulose-5-phosphate synthase3e-0650.4
NC_013714:796442:8171848171848191391956Bifidobacterium dentium Bd1, complete genomedxs 1-deoxy-D-xylulose 5-phosphate synthase4e-0650.1
NC_013131:7401253:7402404740240474044612058Catenulispora acidiphila DSM 44928, complete genomeTransketolase central region6e-0649.7
NC_018750:6315802:6336662633666263386201959Streptomyces venezuelae ATCC 10712, complete genome1-deoxy-D-xylulose 5-phosphate synthase9e-0648.9