Pre_GI: BLASTP Hits

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Query: NC_012943:3777371:3780802 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 3780802, End: 3782142, Length: 1341

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3754000:3754183375418337555231341Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein0781
NC_016768:3774105:3777536377753637788761341Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein0781
NC_009525:3794000:3794055379405537953951341Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein0781
NC_000962:3781501:3784932378493237862721341Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein0781
NC_009565:3793976:3797407379740737987471341Mycobacterium tuberculosis F11, complete genomehypothetical protein0781
NC_002755:3773734:3777165377716537785051341Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein0780
NC_015848:3851230:3854660385466038560001341Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein0778
NC_002945:3735141:3738572373857237399121341Mycobacterium bovis AF2122/97, complete genomehypothetical protein0778
NC_019950:3818000:3818051381805138193911341Mycobacterium canettii CIPT 140060008 complete genomeConserved protein of unknown function, possible triacylglycerol synthase (diacylglycerol acyltransferase)0778
NC_012207:3766978:3770409377040937717491341Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein0778
NC_008769:3769065:3772496377249637738361341Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein0778
NC_016804:3407859:3426050342605034274411392Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative diacylglycerol O-acyltransferase7e-84311
NC_012207:3421144:3439335343933534407261392Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein7e-84311
NC_008769:3427254:3446685344668534480761392Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein7e-84311
NC_002945:3429315:3448747344874734501381392Mycobacterium bovis AF2122/97, complete genomehypothetical protein7e-84311
NC_016887:3201976:3218725321872532200411317Nocardia cyriacigeorgica GUH-2, complete genomediacylglycerol O-acyltransferase9e-53207
NC_008595:2215244:2246608224660822480081401Mycobacterium avium 104, complete genomeacyltransferase, ws/dgat/mgat subfamily protein6e-21102
NC_006361:1720031:1724560172456017259781419Nocardia farcinica IFM 10152, complete genomehypothetical protein1e-20101
NC_009338:5537473:5556568555656855579531386Mycobacterium gilvum PYR-GCK chromosome, complete genomehypothetical protein9e-21101
NC_014366:1435785:1463485146348514649091425Gamma proteobacterium HdN1, complete genomeUncharacterised protein family (UPF0089)4e-1996.3
NC_014366:1814000:1816330181633018178111482Gamma proteobacterium HdN1, complete genomehypothetical protein7e-1892.4
NC_008595:1844500:1844550184455018459381389Mycobacterium avium 104, complete genomeacyltransferase, ws/dgat/mgat subfamily protein5e-1685.9
NC_007645:5160133:5164416516441651657921377Hahella chejuensis KCTC 2396, complete genomehypothetical protein1e-1171.2
NC_011896:1462258:1482841148284114843161476Mycobacterium leprae Br4923, complete genomehypothetical protein4e-1170.1
NC_002677:1462233:1482817148281714842921476Mycobacterium leprae TN, complete genomehypothetical protein4e-1170.1
NC_009348:2125698:2162408216240821638381431Aeromonas salmonicida subsp. salmonicida A449, complete genomehypothetical protein1e-1067.8
NC_007645:1194550:1224986122498612263591374Hahella chejuensis KCTC 2396, complete genomehypothetical protein8e-1065.5
NC_008769:2754828:2754828275482827563031476Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein6e-0962.4
NC_012207:2747599:2747599274759927490741476Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein6e-0962.4
NC_002945:2757821:2757821275782127592961476Mycobacterium bovis AF2122/97, complete genomehypothetical protein6e-0962.4
NC_009525:2802987:2802987280298728044621476Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein6e-0962.4
NC_000962:2791019:2791019279101927924941476Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein6e-0962.4
NC_019673:3582004:3598023359802335994711449Saccharothrix espanaensis DSM 44229 complete genomehypothetical protein8e-0962
NC_016906:3286384:3304246330424633056701425Gordonia polyisoprenivorans VH2 chromosome, complete genomeO-acyltransferase WSD9e-0652