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Query: NC_012943:2707677:2731500 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2731500, End: 2732258, Length: 759

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016768:2704350:272817327281732728931759Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein2e-112405
NC_016801:1255611:130113213011321301884753Corynebacterium diphtheriae C7 (beta) chromosome, complete genomehypothetical protein4e-26118
NC_016782:1251796:125603712560371256768732Corynebacterium diphtheriae 241 chromosome, complete genomehypothetical protein5e-26118
NC_002935:1237585:128238212823821283083702Corynebacterium diphtheriae NCTC 13129, complete genomehypothetical protein6e-26117
NC_016783:1274000:128036612803661281067702Corynebacterium diphtheriae INCA 402 chromosome, complete genomehypothetical protein6e-26117
NC_016785:1233384:123765512376551238356702Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomehypothetical protein6e-26117
NC_016786:1251765:125603612560361256737702Corynebacterium diphtheriae HC01 chromosome, complete genomehypothetical protein6e-26117
NC_016787:1240000:124548912454891246190702Corynebacterium diphtheriae HC03 chromosome, complete genomehypothetical protein6e-26117
NC_016788:1214026:125547812554781256179702Corynebacterium diphtheriae HC04 chromosome, complete genomehypothetical protein6e-26117
NC_016789:1295918:130018913001891300890702Corynebacterium diphtheriae PW8 chromosome, complete genomehypothetical protein6e-26117
NC_016790:1218596:122286712228671223568702Corynebacterium diphtheriae VA01 chromosome, complete genomehypothetical protein6e-26117
NC_016799:1268706:131152313115231312224702Corynebacterium diphtheriae 31A chromosome, complete genomehypothetical protein6e-26117
NC_016800:1243000:128463912846391285340702Corynebacterium diphtheriae BH8 chromosome, complete genomehypothetical protein6e-26117
NC_015859:1631573:165419116541911654871681Corynebacterium variabile DSM 44702 chromosome, complete genomehypothetical protein4e-1995.1
NC_010556:2773396:277921927792192779872654Exiguobacterium sibiricum 255-15, complete genomeSNARE associated Golgi protein3e-1892
NC_003888:3817000:381774538177453818494750Streptomyces coelicolor A3(2), complete genomeintegral membrane protein1e-1686.7
NC_018665:2563375:256901525690152569668654Exiguobacterium antarcticum B7 chromosome, complete genomeSNARE associated Golgi family protein3e-1582.4
NC_009464:180335:190897190897191577681Uncultured methanogenic archaeon RC-I, complete genomehypothetical protein4e-1272
NC_003888:1395319:139846313984631399239777Streptomyces coelicolor A3(2), complete genomeintegral membrane protein7e-1270.9
NC_010516:2777205:279108927910892791808720Clostridium botulinum B1 str. Okra, complete genomeDedA family protein5e-1168.2
NC_017297:2796000:280701528070152807734720Clostridium botulinum F str. 230613 chromosome, complete genomeDedA family protein9e-1167.4
NC_010520:2807429:282162728216272822346720Clostridium botulinum A3 str. Loch Maree, complete genomeDedA family protein2e-1066.2
NC_017297:2796000:280631228063122807049738Clostridium botulinum F str. 230613 chromosome, complete genomeDedA family protein5e-0961.6
NC_010520:2807429:282092428209242821661738Clostridium botulinum A3 str. Loch Maree, complete genomeDedA family protein8e-0960.8
NC_010516:2777205:279038627903862791123738Clostridium botulinum B1 str. Okra, complete genomeDedA family protein4e-0858.5
NC_011884:1821862:182516518251651825836672Cyanothece sp. PCC 7425, complete genomeSNARE associated Golgi protein8e-0857.8
NC_012881:2878000:288545328854532886130678Desulfovibrio salexigens DSM 2638, complete genomeSNARE associated Golgi protein8e-0857.4
NC_015555:693461:707062707062707739678Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeSNARE associated Golgi protein-like protein9e-0650.8