Pre_GI: BLASTP Hits

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Query: NC_012943:2707677:2725578 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2725578, End: 2726582, Length: 1005

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:1679357:1682236168223616832401005Mycobacterium bovis BCG str. Mexico chromosome, complete genomearginine/ornithine transport system ATPase3e-171601
NC_002945:1680751:1683630168363016846341005Mycobacterium bovis AF2122/97, complete genomearginine/ornithine transport system ATPase3e-171601
NC_015848:1708176:1711055171105517120591005Mycobacterium canettii CIPT 140010059, complete genomeputative transport system kinase3e-171601
NC_002755:1684161:1687040168704016880441005Mycobacterium tuberculosis CDC1551, complete genomearginine/ornithine transport system ATPase3e-171601
NC_012207:1681971:1684850168485016858541005Mycobacterium bovis BCG str. Tokyo 172, complete genomearginine/ornithine transport system ATPase3e-171601
NC_009525:1685522:1688401168840116894051005Mycobacterium tuberculosis H37Ra, complete genomearginine/ornithine transport system ATPase3e-171601
NC_008769:1709078:1711957171195717129611005Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transport system kinase3e-171601
NC_009565:1688642:1691521169152116925251005Mycobacterium tuberculosis F11, complete genomearginine/ornithine transport system ATPase3e-171601
NC_000962:1684005:1686884168688416878881005Mycobacterium tuberculosis H37Rv, complete genomearginine/ornithine transport system ATPase3e-171601
NC_016768:2704350:2722251272225127232521002Mycobacterium tuberculosis KZN 4207 chromosome, complete genomearginine/ornithine transport system ATPase1e-170598
NC_019950:1689910:169022416902241691219996Mycobacterium canettii CIPT 140060008 complete genomePutative arginine/ornithine transport system ATPase7e-162570
NC_002944:1285436:128777112877711288751981Mycobacterium avium subsp. paratuberculosis K-10, complete genomearginine/ornithine transport system ATPase8e-135479
NC_002935:1237585:1276921127692112779251005Corynebacterium diphtheriae NCTC 13129, complete genomearginine/ornithine transport system ATPase2e-94346
NC_016787:1240000:1240028124002812411311104Corynebacterium diphtheriae HC03 chromosome, complete genomearginine/ornithine transport system ATPase2e-94346
NC_016788:1214026:1250017125001712511201104Corynebacterium diphtheriae HC04 chromosome, complete genomearginine/ornithine transport system ATPase2e-94346
NC_016801:1255611:1295722129572212968251104Corynebacterium diphtheriae C7 (beta) chromosome, complete genomearginine/ornithine transport system ATPase2e-94346
NC_016799:1268706:1306062130606213071651104Corynebacterium diphtheriae 31A chromosome, complete genomearginine/ornithine transport system ATPase2e-94346
NC_016783:1274000:1274905127490512760081104Corynebacterium diphtheriae INCA 402 chromosome, complete genomearginine/ornithine transport system ATPase3e-94345
NC_016800:1243000:1279178127917812802811104Corynebacterium diphtheriae BH8 chromosome, complete genomearginine/ornithine transport system ATPase9e-94343
NC_009937:1733196:1748289174828917493801092Azorhizobium caulinodans ORS 571, complete genomeArgK protein6e-88324
NC_010505:3690000:369222836922283693214987Methylobacterium radiotolerans JCM 2831, complete genomeLAO/AO transport system ATPase6e-86317
NC_014758:579741:592712592712593692981Calditerrivibrio nitroreducens DSM 19672 chromosome, completemethylmalonyl-CoA mutase metallochaperone meab8e-81300
NC_012793:2337776:2337776233777623388761101Geobacillus sp. WCH70, complete genomeLAO/AO transport system ATPase9e-79293
NC_011992:1968258:1970417197041719714451029Acidovorax ebreus TPSY, complete genomeLAO/AO transport system ATPase1e-78293
NC_010729:1818500:1836144183614418372501107Porphyromonas gingivalis ATCC 33277, complete genomearginine/ornithine transport system ATPase4e-77288
NC_002950:353549:3547883547883558191032Porphyromonas gingivalis W83, complete genomearginine/ornithine transport system ATPase4e-77288
NC_010814:3474856:348605334860533487021969Geobacter lovleyi SZ, complete genomeLAO/AO transport system ATPase1e-74280
NC_013446:2655955:2657571265757126585751005Comamonas testosteroni CNB-2, complete genomeLAO/AO transport system ATPase5e-74278
NC_013411:284461:2866532866532878011149Geobacillus sp. Y412MC61, complete genomeLAO/AO transport system ATPase9e-74277
NC_014915:2427000:2451687245168724528351149Geobacillus sp. Y412MC52 chromosome, complete genomeLAO/AO transport system ATPase9e-74277
NC_011565:423000:4277584277584288491092Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,arginine/ornithine transport system ATPase1e-72273
NC_015496:2279829:2280386228038622814321047Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomeLAO/AO transport system ATPase1e-72273
NC_020156:49666:6235562355633681014Nonlabens dokdonensis DSW-6, complete genomeArgK protein8e-70264
NC_015144:900000:900004900004900969966Weeksella virosa DSM 16922 chromosome, complete genomeLAO/AO transporter ATPase6e-62238
NC_007512:1459685:1463592146359214646051014Pelodictyon luteolum DSM 273, complete genomearginine/ornithine transport system ATPase1e-59229
NC_015958:2361551:236854623685462369481936Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeLAO/AO transport system ATPase1e-49197
NC_016148:1105669:111658811165881117541954Thermovirga lienii DSM 17291 chromosome, complete genomeLAO/AO transport system ATPase4e-47188
NC_014633:837588:869031869031869969939Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceLAO/AO transport system ATPase5e-45181
NC_009922:490500:495211495211496152942Alkaliphilus oremlandii OhILAs, complete genomeLAO/AO transport system ATPase8e-43174
NC_014964:923681:948002948002948931930Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeLAO/AO transport system ATPase1e-41170
NC_014538:1075720:108431110843111085240930Thermoanaerobacter sp. X513 chromosome, complete genomeLAO/AO transport system ATPase1e-41170
NC_010320:1860801:186910418691041870033930Thermoanaerobacter sp. X514 chromosome, complete genomeLAO/AO transport system ATPase1e-41170
NC_010321:947233:955809955809956738930Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeLAO/AO transport system ATPase1e-41170
NC_014221:591785:610317610317611249933Truepera radiovictrix DSM 17093 chromosome, complete genomeLAO/AO transport system ATPase2e-41169
NC_015437:572788:573318573318574256939Selenomonas sputigena ATCC 35185 chromosome, complete genomeLAO/AO transport system ATPase4e-40165
NC_016584:1583685:160046716004671601423957Desulfosporosinus orientis DSM 765 chromosome, complete genomeLAO/AO transport system ATPase2e-39163
NC_009454:1462930:147108014710801472003924Pelotomaculum thermopropionicum SI, complete genomeperiplasmic protein kinase ArgK4e-39162
NC_009718:1411793:142706314270631428001939Fervidobacterium nodosum Rt17-B1, complete genomeLAO/AO transport system ATPase1e-38160
NC_014829:4422314:443620144362014437178978Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeLAO/AO transport system ATPase3e-38159
NC_002689:770326:790007790007790954948Thermoplasma volcanium GSS1, complete genomePredicted GTPase (G3E family)2e-37156
NC_011146:3089297:311245831124583113402945Geobacter bemidjiensis Bem, complete genomeLAO/AO transport system ATPase1e-36154
NC_008699:2260606:227896422789642279947984Nocardioides sp. JS614, complete genomeLAO/AO transport system ATPase9e-37154
NC_014374:1072218:108296310829631083961999Acidilobus saccharovorans 345-15 chromosome, complete genomeTransport system kinase1e-36153
NC_010003:605961:605961605961606893933Petrotoga mobilis SJ95, complete genomeArgK protein9e-35147
NC_007517:2494000:250072325007232501715993Geobacter metallireducens GS-15, complete genomeArgK protein9e-35147
NC_019942:987134:105254210525421053492951Aciduliprofundum sp. MAR08-339, complete genomeLAO/AO transport system ATPase2e-33143
NC_008699:833737:844711844711845610900Nocardioides sp. JS614, complete genomeLAO/AO transport system ATPase2e-30133
NC_005877:284829:305475305475306347873Picrophilus torridus DSM 9790, complete genomeLAO/AO transport system kinase ArgK4e-30132
NC_016943:4194002:4203312420331242043131002Blastococcus saxobsidens DD2, complete genomeputative lysine arginine ornithine transport system kinase1e-23110
NC_016023:1538000:1542435154243515456893255Bacillus coagulans 36D1 chromosome, complete genomemethylmalonyl-CoA mutase large subunit4e-2099
NC_014307:3179100:3198237319823732015363300Ralstonia solanacearum CFBP2957 chromosome, complete genomemethylmalonyl-CoA mutase1e-1894.4
NC_013061:1360081:1374974137497413783693396Pedobacter heparinus DSM 2366, complete genomeMethylmalonyl-CoA mutase7e-1891.7
NC_002570:3911153:3914942391494239182053264Bacillus halodurans C-125, complete genomehypothetical protein1e-1791.3
NC_014829:4422314:4432925443292544361793255Bacillus cellulosilyticus DSM 2522 chromosome, complete genomemethylmalonyl-CoA mutase, large subunit1e-1687
NC_010382:1020516:1030477103047710337253249Lysinibacillus sphaericus C3-41, complete genomeputative methylmalonyl-CoA mutase protein5e-1685.5
NC_021171:4674086:4676952467695246802183267Bacillus sp. 1NLA3E, complete genomemethylmalonyl-CoA mutase protein9e-1581.3
NC_020541:2694836:2707800270780027114803681Rhodanobacter sp. 2APBS1, complete genomemethylmalonyl-CoA mutase, N-terminal domain/subunit4e-1375.9