Pre_GI: BLASTP Hits

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Query: NC_012943:2707677:2723546 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2723546, End: 2724163, Length: 618

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1686500:169031916903191690936618Mycobacterium tuberculosis RGTB327 chromosome, complete genomemethyltransferase5e-120429
NC_012207:1681971:168726916872691687886618Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative methyltransferase5e-120429
NC_019950:1689910:169264516926451693262618Mycobacterium canettii CIPT 140060008 complete genomePutative methyltransferase5e-120429
NC_008769:1709078:171437617143761714993618Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative methyltransferase5e-120429
NC_009565:1688642:169394016939401694557618Mycobacterium tuberculosis F11, complete genomehypothetical methyltransferase5e-120429
NC_002945:1680751:168604916860491686666618Mycobacterium bovis AF2122/97, complete genomemethyltransferase5e-120429
NC_016768:2704350:272021927202192720836618Mycobacterium tuberculosis KZN 4207 chromosome, complete genomemethyltransferase5e-120429
NC_016804:1679357:168465516846551685272618Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative methyltransferase5e-120429
NC_000962:1684005:168930316893031689920618Mycobacterium tuberculosis H37Rv, complete genomePROBABLE METHYLTRANSFERASE3e-119427
NC_009525:1685522:169082016908201691437618Mycobacterium tuberculosis H37Ra, complete genomemethyltransferase3e-119427
NC_015848:1708176:171347417134741714091618Mycobacterium canettii CIPT 140010059, complete genomeputative methyltransferase5e-119426
NC_002755:1684161:168945916894591690076618Mycobacterium tuberculosis CDC1551, complete genomemethyltransferase4e-119426
NC_011894:6888562:694564669456466946569924Methylobacterium nodulans ORS 2060, complete genomeMethyltransferase type 114e-44177
NC_011757:4445343:445837344583734459254882Methylobacterium chloromethanicum CM4, complete genomeMethyltransferase type 116e-24110
NC_008508:1382036:139473413947341395468735Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1,Methylase/methyltransferase8e-1063.5
NC_008510:1339926:135261513526151353349735Leptospira borgpetersenii serovar Hardjo-bovis JB197 chromosome 1,Methylase/methyltransferase8e-1063.5
NC_016109:5290000:530951253095125310330819Kitasatospora setae KM-6054, complete genomehypothetical protein4e-0961.2
NC_011894:2811573:2811573281157328130211449Methylobacterium nodulans ORS 2060, complete genomeMethyltransferase type 112e-0858.9
NC_011832:1148859:115420011542001155012813Candidatus Methanosphaerula palustris E1-9c, complete genomeMethyltransferase type 117e-0857
NC_011894:2811573:2816870281687028182851416Methylobacterium nodulans ORS 2060, complete genomeMethyltransferase type 117e-0857
NC_014844:762794:772362772362773180819Desulfovibrio aespoeensis Aspo-2 chromosome, complete genometype 11 methyltransferase1e-0756.6
NC_015856:940625:969089969089969964876Collimonas fungivorans Ter331 chromosome, complete genomeputative glycosyltransferase1e-0756.2
NC_016109:62000:684276842769281855Kitasatospora setae KM-6054, complete genomeputative methyltransferase1e-0756.2
NC_016109:8664974:871399887139988714852855Kitasatospora setae KM-6054, complete genomeputative methyltransferase1e-0756.2
NC_011832:1148859:115782311578231158647825Candidatus Methanosphaerula palustris E1-9c, complete genomeMethyltransferase type 113e-0755.5
NC_014010:1020488:105214310521431052946804Candidatus Puniceispirillum marinum IMCC1322 chromosome, completehypothetical protein3e-0755.1
NC_007802:1991211:202540220254022026187786Jannaschia sp. CCS1, complete genomeMethyltransferase type 116e-0753.9
NC_014804:1183780:121389612138961214483588Thermococcus barophilus MP chromosome, complete genome2-heptaprenyl-1/4-naphthoquinone methyltransferase6e-0753.9
NC_010545:1781393:180109018010901801974885Corynebacterium urealyticum DSM 7109, complete genomehypothetical protein7e-0753.9
NC_014171:261952:296908296908297780873Bacillus thuringiensis BMB171 chromosome, complete genomemethyltransferase2e-0652.4
NC_017208:256163:287030287030287902873Bacillus thuringiensis serovar chinensis CT-43 chromosome, completemethyltransferase3e-0651.6