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Query: NC_012943:2707677:2723120 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2723120, End: 2723332, Length: 213

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1686500:169115016911501691362213Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein1e-34144
NC_009565:1688642:169477116947711694983213Mycobacterium tuberculosis F11, complete genomehypothetical protein1e-34144
NC_000962:1684005:169013416901341690346213Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein1e-34144
NC_009525:1685522:169165116916511691863213Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein1e-34144
NC_002755:1684161:169029016902901690502213Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein1e-34144
NC_015848:1708176:171430517143051714517213Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein1e-34144
NC_016768:2704350:271979327197932720005213Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein1e-34144
NC_019950:1689910:169347616934761693688213Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein3e-34143
NC_002945:1680751:168688016868801687071192Mycobacterium bovis AF2122/97, complete genomehypothetical protein1e-29128
NC_012207:1681971:168810016881001688291192Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein1e-29128
NC_008769:1709078:171520717152071715398192Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein1e-29128
NC_016804:1679357:168548616854861685677192Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein1e-29128
NC_021150:201237:204204204204204419216Azotobacter vinelandii CA6, complete genomehypothetical protein3e-1787.4
NC_012560:201237:204204204204204419216Azotobacter vinelandii DJ, complete genomehypothetical protein3e-1787.4
NC_002927:1787633:180566418056641805879216Bordetella bronchiseptica RB50, complete genomehypothetical protein2e-1684.7
NC_003296:1461538:148168314816831481934252Ralstonia solanacearum GMI1000 plasmid pGMI1000MP, completehypothetical protein2e-1684.3
NC_007760:2126956:214600321460032146206204Anaeromyxobacter dehalogenans 2CP-C, complete genomeprotein of unknown function DUF14588e-1165.9
NC_010831:40000:403494034940564216Chlorobium phaeobacteroides BS1, complete genomeprotein of unknown function DUF14582e-1064.3
NC_007517:3524715:354455635445563544777222Geobacter metallireducens GS-15, complete genomeprotein of unknown function DUF14584e-0753.5