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Query: NC_012943:2707677:2722661 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2722661, End: 2723059, Length: 399

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002755:1684161:169049116904911690961471Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein2e-64243
NC_015848:1708176:171457817145781714976399Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein2e-64243
NC_008769:1709078:171548017154801715878399Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-64243
NC_009565:1688642:169504416950441695442399Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-64243
NC_000962:1684005:169040716904071690805399Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein2e-64243
NC_002945:1680751:168715316871531687551399Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-64243
NC_012207:1681971:168837316883731688771399Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-64243
NC_009525:1685522:169192416919241692322399Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein2e-64243
NC_016768:2704350:271933427193342719732399Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein2e-64243
NC_016804:1679357:168575916857591686157399Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein2e-64243
NC_017026:1686500:169142316914231691821399Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein2e-64243
NC_019950:1689910:169374916937491694144396Mycobacterium canettii CIPT 140060008 complete genome1e-61234