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Query: NC_012943:2707677:2720755 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2720755, End: 2721576, Length: 822

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1686500:169290616929061693727822Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein6e-161566
NC_002945:1680751:168863616886361689457822Mycobacterium bovis AF2122/97, complete genomehypothetical protein6e-161566
NC_002755:1684161:169204616920461692867822Mycobacterium tuberculosis CDC1551, complete genomemmcH protein, putative6e-161566
NC_012207:1681971:168985616898561690677822Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein6e-161566
NC_008769:1709078:171696317169631717784822Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein6e-161566
NC_015848:1708176:171606117160611716882822Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein6e-161566
NC_009525:1685522:169340716934071694228822Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein6e-161566
NC_000962:1684005:169189016918901692711822Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein6e-161566
NC_016768:2704350:271742827174282718249822Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein6e-161566
NC_016804:1679357:168724216872421688063822Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein6e-161566
NC_009565:1688642:169652716965271697348822Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-160564
NC_019950:1689910:169523216952321696053822Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein4e-160563
NC_010612:2777687:278257227825722783393822Mycobacterium marinum M, complete genomehypothetical protein4e-132470
NC_009719:3532587:355131635513163552140825Parvibaculum lavamentivorans DS-1 chromosome, complete genomephytanoyl-CoA dioxygenase7e-27120
NC_014539:860402:866254866254867072819Burkholderia sp. CCGE1003 chromosome 1, complete sequencePhytanoyl-CoA dioxygenase2e-2099.4
NC_010622:2576110:258842825884282589261834Burkholderia phymatum STM815 chromosome 1, complete sequencePhytanoyl-CoA dioxygenase1e-1790.5
NC_008380:855246:869484869484870305822Rhizobium leguminosarum bv. viciae 3841, complete genomeputative deoxygenase5e-1788.2
NC_017904:4203257:420854942085494209412864Mycobacterium sp. MOTT36Y chromosome, complete genomephytanoyl-CoA dioxygenase (PhyH) family protein2e-1169.7
NC_018643:1037456:104413410441341044949816Alpha proteobacterium HIMB5 chromosome, complete genomePhytanoyl-CoA dioxygenase (PhyH)2e-0963.2
NC_007509:309348:319418319418320296879Burkholderia sp. 383 chromosome 3, complete sequencePhytanoyl-CoA dioxygenase5e-0962
NC_011770:3396637:340830234083023409174873Pseudomonas aeruginosa LESB58, complete genomehypothetical protein6e-0858.2
NC_014623:4662990:467129846712984672137840Stigmatella aurantiaca DW4/3-1 chromosome, complete genomephytanoyl-CoA dioxygenase5e-0755.1
NC_016830:1645879:166220716622071662953747Pseudomonas fluorescens F113 chromosome, complete genomePhytanoyl-CoA dioxygenase2e-0653.1