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Query: NC_012943:2707677:2719643 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2719643, End: 2720542, Length: 900

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1686500:169394016939401694839900Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein8e-174609
NC_012207:1681971:169089016908901691789900Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein8e-174609
NC_009565:1688642:169756116975611698460900Mycobacterium tuberculosis F11, complete genomehypothetical protein8e-174609
NC_002755:1684161:169308016930801693979900Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein8e-174609
NC_015848:1708176:171709517170951717994900Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein8e-174609
NC_008769:1709078:171799717179971718896900Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein8e-174609
NC_016768:2704350:271631627163162717215900Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein8e-174609
NC_016804:1679357:168827616882761689175900Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein8e-174609
NC_000962:1684005:169292416929241693823900Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein1e-172605
NC_009525:1685522:169444116944411695340900Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein1e-172605
NC_019950:1689910:169626616962661697165900Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein2e-172605
NC_010612:2777687:278635927863592787267909Mycobacterium marinum M, complete genomehypothetical protein7e-128456
NC_002945:1680751:168999916899991690568570Mycobacterium bovis AF2122/97, complete genomehypothetical protein1e-108393
NC_008702:2942246:295333429533342954254921Azoarcus sp. BH72, complete genomeconserved hypothetical protein2e-66252
NC_009719:3532587:355213335521333553074942Parvibaculum lavamentivorans DS-1 chromosome, complete genomehypothetical protein1e-63243
NC_008380:855246:866143866143867084942Rhizobium leguminosarum bv. viciae 3841, complete genomehypothetical protein3e-57221
NC_007651:3656433:366194336619433662902960Burkholderia thailandensis E264 chromosome I, complete sequencehypothetical protein2e-55216
NC_002945:1680751:168967016896701690020351Mycobacterium bovis AF2122/97, complete genomehypothetical protein3e-55215
NC_012883:1817358:183728718372871838213927Thermococcus sibiricus MM 739, complete genomehypothetical protein1e-40167
NC_004547:1970686:198247719824771983436960Erwinia carotovora subsp. atroseptica SCRI1043, complete genomehypothetical protein5e-38158
NC_012917:2921932:293288229328822933841960Pectobacterium carotovorum subsp. carotovorum PC1, complete genomehypothetical protein6e-38157
NC_012917:2921932:293191429319142932882969Pectobacterium carotovorum subsp. carotovorum PC1, complete genomehypothetical protein3e-33142
NC_010622:2576110:258748225874822588405924Burkholderia phymatum STM815 chromosome 1, complete sequencehypothetical protein8e-32137
NC_004547:1970686:198343619834361984404969Erwinia carotovora subsp. atroseptica SCRI1043, complete genomehypothetical protein8e-31134
NC_014539:860402:867089867089868015927Burkholderia sp. CCGE1003 chromosome 1, complete sequencehypothetical protein5e-28125