Pre_GI: BLASTP Hits

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Query: NC_012943:2707677:2717520 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2717520, End: 2718185, Length: 666

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1686500:169630016963001696965666Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein5e-116416
NC_008769:1709078:172035417203541721019666Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein5e-116416
NC_012207:1681971:169324716932471693912666Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein5e-116416
NC_015848:1708176:171945217194521720117666Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein5e-116416
NC_002945:1680751:169202616920261692691666Mycobacterium bovis AF2122/97, complete genomehypothetical protein5e-116416
NC_000962:1684005:169528116952811695946666Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein5e-116416
NC_009565:1688642:169991816999181700583666Mycobacterium tuberculosis F11, complete genomehypothetical protein5e-116416
NC_009525:1685522:169679816967981697463666Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein5e-116416
NC_019950:1689910:170003717000371700702666Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein5e-116416
NC_016768:2704350:271419327141932714858666Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein5e-116416
NC_016804:1679357:169063316906331691298666Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein5e-116416
NC_002755:1684161:169543716954371696102666Mycobacterium tuberculosis CDC1551, complete genometransferase, putative1e-115415
NC_010612:2777687:279024027902402790905666Mycobacterium marinum M, complete genomeconserved hypothetical acyltransferase5e-107386
NC_009719:3532587:354436435443643545029666Parvibaculum lavamentivorans DS-1 chromosome, complete genomehexapaptide repeat-containing transferase5e-83306
NC_008380:855246:867081867081867746666Rhizobium leguminosarum bv. viciae 3841, complete genomeputative hexapeptide repeat transferase5e-78290
NC_008702:2942246:295428529542852954947663Azoarcus sp. BH72, complete genomeconserved hypothetical protein, possibly an acyltransferase5e-70263
NC_009654:894492:912244912244912906663Marinomonas sp. MWYL1, complete genomeacyltransferase2e-61235
NC_007651:3656433:366127336612733661932660Burkholderia thailandensis E264 chromosome I, complete sequencetransferase, putative3e-47188
NC_010622:2576110:259611825961182596795678Burkholderia phymatum STM815 chromosome 1, complete sequencetransferase hexapeptide repeat containing protein5e-47187
NC_012883:1817358:183821018382101838953744Thermococcus sibiricus MM 739, complete genomehypothetical protein2e-44178
NC_007796:3379614:339302133930213393680660Methanospirillum hungatei JF-1, complete genometransferase hexapeptide repeat6e-43173
NC_009483:2640403:272601327260132726741729Geobacter uraniireducens Rf4 chromosome, complete genomeUDP-glucose 4-epimerase2e-42172
NC_013642:400651:428744428744429376633Thermotoga naphthophila RKU-10, complete genomesugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family4e-1168.2
NC_011060:514874:516058516058516687630Pelodictyon phaeoclathratiforme BU-1, complete genometransferase hexapeptide repeat containing protein3e-1065.1
NC_015660:391627:406751406751407383633Geobacillus thermoglucosidasius C56-YS93 chromosome, completesugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family4e-1064.7
NC_010336:1248071:127161312716131272194582Francisella philomiragia subsp. philomiragia ATCC 25017, completeacetyl transferase9e-1063.5
NC_014387:497883:548856548856549515660Butyrivibrio proteoclasticus B316 chromosome 1, complete genomeacetyltransferase1e-0963.2
NC_006510:3133965:314431831443183144950633Geobacillus kaustophilus HTA426, complete genomehypothetical protein2e-0962.8
NC_012660:1804610:182800518280051828670666Pseudomonas fluorescens SBW25 chromosome, complete genomeputative transferase2e-0962.8
NC_007517:2632233:264067626406762641338663Geobacter metallireducens GS-15, complete genometransferase hexapeptide repeat protein3e-0962
NC_009699:2875386:289729728972972897935639Clostridium botulinum F str. Langeland chromosome, complete genomehexapeptide repeat-containing transferase4e-0961.6
NC_014387:2661496:267818626781862678842657Butyrivibrio proteoclasticus B316 chromosome 1, complete genomeacetyltransferase6e-0960.8
NC_013522:736339:736339736339737004666Thermanaerovibrio acidaminovorans DSM 6589, complete genomecarbonic anhydrase6e-0960.8
NC_014117:3375796:338263933826393383274636Burkholderia sp. CCGE1002 chromosome chromosome 1, completeUDP-3-O-(3-hydroxymyristoyl)-like protein1e-0859.7
NC_015424:3112637:314097631409763141617642Aeromonas veronii B565 chromosome, complete genomecarbonic anhydrase/acetyltransferase isoleucine patch superfamily-like protein2e-0858.9
NC_012491:5628000:564110956411095641741633Brevibacillus brevis NBRC 100599, complete genomehypothetical protein3e-0858.5
NC_007575:601256:602407602407602982576Sulfurimonas denitrificans DSM 1251, complete genomeacetyl transferase4e-0858.2
NC_016745:2913712:292259929225992923237639Oceanimonas sp. GK1 chromosome, complete genomeisoleucine patch superfamily carbonic anhydrase/acetyltransferase5e-0857.8
NC_005363:1604337:162101216210121621671660Bdellovibrio bacteriovorus HD100, complete genomehexapeptide transferase family protein7e-0857.4
NC_019892:3030737:304382330438233044509687Singulisphaera acidiphila DSM 18658 chromosome, complete genomesugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family1e-0757
NC_017187:641822:647410647410647985576Arcobacter butzleri ED-1, complete genomeacetyl transferase2e-0756.2
NC_005139:305420:322590322590323225636Vibrio vulnificus YJ016 chromosome I, complete sequenceputative acetyltransferase2e-0756.2
NC_016148:1877711:188324718832471883894648Thermovirga lienii DSM 17291 chromosome, complete genomesugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family2e-0756.2
NC_016593:3402205:341881234188123419444633Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completesugar O-acyltransferase, sialic acid O-acetyltransferase NeuD3e-0755.5
NC_011831:2410607:244564724456472446336690Chloroflexus aggregans DSM 9485, complete genomehexapaptide repeat-containing transferase4e-0755.1
NC_015732:529201:553859553859554431573Spirochaeta caldaria DSM 7334 chromosome, complete genomesugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family8e-0753.9
NC_007677:771168:796509796509797138630Salinibacter ruber DSM 13855, complete genomepilin glycosylation protein PglB1e-0653.1
NC_014206:3468500:347082834708283471460633Geobacillus sp. C56-T3 chromosome, complete genomesugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family2e-0652.8
NC_013956:2523955:253841925384192538886468Pantoea ananatis LMG 20103 chromosome, complete genomeMaa3e-0652
NC_017271:2278500:228914122891412289764624Xanthomonas campestris pv. raphani 756C chromosome, completehypothetical protein5e-0651.6
NC_008570:3220539:325324632532463253863618Aeromonas hydrophila subsp. hydrophila ATCC 7966, complete genomeacetyltransferase5e-0651.2
NC_002939:3303989:3314633331463333157481116Geobacter sulfurreducens PCA, complete genomehexapeptide transferase family protein6e-0650.8
NC_016935:3994500:401458540145854015181597Paenibacillus mucilaginosus 3016 chromosome, complete genometransferase hexapeptide repeat containing protein6e-0650.8
NC_015690:3438288:345870934587093459305597Paenibacillus mucilaginosus KNP414 chromosome, complete genometransferase hexapeptide repeat containing protein6e-0650.8