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Query: NC_012943:2707677:2717023 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2717023, End: 2717523, Length: 501

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1686500:169696216969621697480519Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein4e-92336
NC_002755:1684161:169609916960991696617519Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein4e-92336
NC_016768:2704350:271369627136962714196501Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein4e-92336
NC_015848:1708176:172011417201141720614501Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein4e-92336
NC_019950:1689910:170069917006991701199501Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein4e-92336
NC_009565:1688642:170058017005801701080501Mycobacterium tuberculosis F11, complete genomehypothetical protein4e-92336
NC_000962:1684005:169594316959431696443501Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein4e-92336
NC_009525:1685522:169746016974601697960501Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein4e-92336
NC_010612:2777687:279090227909022791537636Mycobacterium marinum M, complete genomehypothetical protein6e-74276
NC_009719:3532587:354371735437173544364648Parvibaculum lavamentivorans DS-1 chromosome, complete genomeSAM-binding motif-containing protein2e-51201
NC_008380:855246:867749867749868345597Rhizobium leguminosarum bv. viciae 3841, complete genomehypothetical protein1e-50198
NC_007954:1494291:151339515133951514024630Shewanella denitrificans OS217, complete genomeMethyltransferase type 122e-1684.7
NC_008228:3679949:369216636921663692792627Pseudoalteromonas atlantica T6c, complete genomeMethyltransferase type 126e-1683.6
NC_009464:650997:687412687412688089678Uncultured methanogenic archaeon RC-I, complete genomehypothetical protein2e-1272
NC_009925:5838500:584759958475995848276678Acaryochloris marina MBIC11017, complete genomehypothetical protein5e-1167
NC_011898:3973627:398594339859433986554612Clostridium cellulolyticum H10, complete genomeMethyltransferase type 112e-1065.1
NC_007651:3656433:366064136606413661273633Burkholderia thailandensis E264 chromosome I, complete sequencehypothetical protein1e-0756.2
NC_014484:591291:605459605459606082624Spirochaeta thermophila DSM 6192 chromosome, complete genomeputative SAM-dependent methyltransferase4e-0650.8