Some Help

Query: NC_012943:2707677:2710873 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2710873, End: 2712171, Length: 1299

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia

SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016768:2704350:2707546270754627088441299Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein2e-172605
NC_009525:1685522:1702812170281217041101299Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein2e-172605
NC_019950:1689910:1706055170605517073531299Mycobacterium canettii CIPT 140060008 complete genomeConserved membrane protein of unknown function2e-172605
NC_015848:1708176:1725470172547017267681299Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein2e-172605
NC_000962:1684005:1701295170129517025931299Mycobacterium tuberculosis H37Rv, complete genomeconserved probable membrane protein2e-172605
NC_009565:1688642:1705932170593217072301299Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-172605
NC_017026:1686500:1702357170235717036281272Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein4e-166584
NC_002755:1684161:170145117014511701969519Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein4e-82305
NC_002755:1684161:170197817019781702748771Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein3e-79295
NC_004369:371109:3829443829443842121269Corynebacterium efficiens YS-314, complete genomehypothetical protein4e-29129
NC_015145:2693749:2700292270029227014551164Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genomehypothetical protein7e-22105
NC_007164:2261644:2261644226164422629181275Corynebacterium jeikeium K411, complete genomehypothetical protein2e-20100